M6418

Manumycin A from Streptomyces parvulus

• Empirical Formula (Hill Notation): C₃₁H₃₈N₂O₇
• CAS Number: 52665-74-4
• Molecular Weight: 550.64
• MDL number: MFCD00920782
• UNSPSC Code: 12352200
• PubChem Substance ID: 24897011
• NACRES: NA.32

Properties

• Assay: ≥97% (HPLC)
• Quality Level: 200
• form: powder
• solubility: methanol: 9.80-10.20 mg/mL, clear, yellow to very deep yellow
• storage temp.: 2-8°C
• SMILES string: CCCC[C@@H](C)\C=C(C)\C=C(/C)C(=O)NC1=C[C@@](O)(\C=C\C=C\C=C\C(=O)NC2=C(O)CCC2=O)[C@@H]3O[C@H]3C1=O
• InChI: 1S/C31H38N2O7/c1-5-6-11-19(2)16-20(3)17-21(4)30(38)32-22-18-31(39,29-28(40-29)27(22)37)15-10-8-7-9-12-25(36)33-26-23(34)13-14-24(26)35/h7-10,12,15-19,28-29,34,39H,5-6,11,13-14H2,1-4H3,(H,32,38)(H,33,36)/b8-7+,12-9+,15-10+,20-16+,21-17+/t19-,28?,29-,31+/m1/s1
• InChI key: TWWQHCKLTXDWBD-YCWSEAROSA-N

Description

Application

Manumycin A from Streptomyces parvulus has been used to inhibit IκB kinase (IKK)b−nuclear κ-B essential modulator (NEMO) interaction in the homogeneous time-resolved fluorescence (HTRF)-based binding assay.

Biochem/physiol Actions

Manumycin A is a natural monomeric epoxyquinoid. It has an ability to inhibit tumor necrosis factor (TNF) induced IκB kinase (IKK) activity in various cell types. In addition, manumycin A exhibits anti-tumor property by inhibiting farnesylation of oncogenic Ras.

Potent inhibitor of Ras farnesyltransferase.

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves