I7659

Monoclonal Anti-Interleukin-1α antibody produced in mouse

clone 3405, purified immunoglobulin, lyophilized powder

• Synonym(s): Anti-IL-1α
• MDL number: MFCD01632982
• UNSPSC Code: 51111800
• NACRES: NA.41

Properties

• biological source: mouse
• conjugate: unconjugated
• antibody form: purified immunoglobulin
• antibody product type: primary antibodies
• clone: 3405, monoclonal
• form: lyophilized powder
• species reactivity: human
• technique(s): flow cytometry: 25 μg/mL; neutralization: suitable
• isotype: IgG1
• UniProt accession no.: P01583
• storage temp.: −20°C
• target post-translational modification: unmodified
• Gene Information: human ... IL1A(3552)

Description

Immunogen

purified, E. coli-derived recombinant human interleukin-1α.

Biochem/physiol Actions

Interleukins are proinflammatory cytokines produced on cell injury or trauma. There are two closely related types of interleukins produced by the cell, IL-1α and IL-1β that are produced in response to bacterial infection or LPS. Both IL-1α and IL-1β exert their cellular effects by signaling through IL-1 receptor type 1. The effects of IL-1α are mediated by activation of NF-κB, JNK and MAPK pathways that activated the genes in response to infection and inflammation. Overproduction of IL-1α has been implicated in inflammatory disorders like rheumatoid arthritis and periodontitis.

Physical form

Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline with 5% trehalose.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.