HPA045025
Anti-FZD8 antibody produced in rabbit
Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution
Synonym(s):
Anti-Frizzled homolog 8 (Drosophila)
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About This Item
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biological source
rabbit
Quality Level
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
product line
Prestige Antibodies® Powered by Atlas Antibodies
form
buffered aqueous glycerol solution
species reactivity
human
technique(s)
immunoblotting: 0.04-0.4 μg/mL
immunohistochemistry: 1:50-1:200
immunogen sequence
GSLYSDVSTGLTWRSGTASSVSYPKQMPLSQV
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... FZD8(8325)
General description
Frizzled class receptor 8 (FZD8) belongs to the frizzled family of receptors and encodes a wingless/integrase-1 (WNT) receptor. It consists of frizzled like cysteine-rich domain, seven transmembrane domains, and a C-terminal Ser/Thr-X-Val motif. The protein is expressed in brain, kidney, heart, pancreas and skeletal muscle. The gene is located on human chromosome 10p11.21. It is a cancer associated gene.
Immunogen
frizzled class receptor 8
Application
All Prestige Antibodies Powered by Atlas Antibodies are developed and validated by the Human Protein Atlas (HPA) project and as a result, are supported by the most extensive characterization in the industry.
The Human Protein Atlas project can be subdivided into three efforts: Human Tissue Atlas, Cancer Atlas, and Human Cell Atlas. The antibodies that have been generated in support of the Tissue and Cancer Atlas projects have been tested by immunohistochemistry against hundreds of normal and disease tissues and through the recent efforts of the Human Cell Atlas project, many have been characterized by immunofluorescence to map the human proteome not only at the tissue level but now at the subcellular level. These images and the collection of this vast data set can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. We also provide Prestige Antibodies® protocols and other useful information.
The Human Protein Atlas project can be subdivided into three efforts: Human Tissue Atlas, Cancer Atlas, and Human Cell Atlas. The antibodies that have been generated in support of the Tissue and Cancer Atlas projects have been tested by immunohistochemistry against hundreds of normal and disease tissues and through the recent efforts of the Human Cell Atlas project, many have been characterized by immunofluorescence to map the human proteome not only at the tissue level but now at the subcellular level. These images and the collection of this vast data set can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. We also provide Prestige Antibodies® protocols and other useful information.
Anti-FZD8 antibody produced in rabbit has been used in immunohistochemistry and western blotting.
Biochem/physiol Actions
Frizzled class receptor 8 (FZD8) plays an important role in airway inflammation linked to chronic bronchitis. Downregulation of this protein is related to microRNA-520b (miR-520b) inhibited cell proliferation, migration, and invasion of spinal osteosarcoma cells. It functions as a potential therapeutic target for prostate cancer bone metastasis. The protein activates β-catenin-TCF pathway and is important in several tumors.
Features and Benefits
Prestige Antibodies® are highly characterized and extensively validated antibodies with the added benefit of all available characterization data for each target being accessible via the Human Protein Atlas portal linked just below the product name at the top of this page. The uniqueness and low cross-reactivity of the Prestige Antibodies® to other proteins are due to a thorough selection of antigen regions, affinity purification, and stringent selection. Prestige antigen controls are available for every corresponding Prestige Antibody and can be found in the linkage section.
Every Prestige Antibody is tested in the following ways:
Every Prestige Antibody is tested in the following ways:
- IHC tissue array of 44 normal human tissues and 20 of the most common cancer type tissues.
- Protein array of 364 human recombinant protein fragments.
Linkage
Corresponding Antigen APREST83761
Physical form
Solution in phosphate buffered saline, pH 7.2, containing 40% glycerol and 0.02% sodium azide.
Legal Information
Prestige Antibodies is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class Code
10 - Combustible liquids
WGK
WGK 1
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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Jennifer A Bohn et al.
Nucleic acids research, 46(1), 362-386 (2017-11-23)
Human Pumilio proteins, PUM1 and PUM2, are sequence specific RNA-binding proteins that regulate protein expression. We used RNA-seq, rigorous statistical testing and an experimentally derived fold change cut-off to identify nearly 1000 target RNAs-including mRNAs and non-coding RNAs-that are functionally
Molecular cloning and characterization of human Frizzled-8 gene on chromosome 10p11.2
Saitoh T, et al.
International Journal of Oncology, 18(5), 991-996 (2001)
Microrna-520b suppresses proliferation, migration, and invasion of spinal osteosarcoma cells via downregulation of frizzled-8
Wang J, et al.
Oncology Research, 25(8), 1297-1304 (2017)
FZD8, a target of p53, promotes bone metastasis in prostate cancer by activating canonical Wnt/beta-catenin signaling
Liet Q, et al.
Cancer Letters, 402(8), 166-176 (2017)
Frizzled 8 promotes the cell proliferation and metastasis of renal cell carcinoma
Yang Q, et al.
Oncotarget, 8(45), 78989-78989 (2017)
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