H0536
Hepatocyte Growth Factor Receptor (c-Met)/Fc Chimera human
>95% (SDS-PAGE), recombinant, expressed in NSO cells, lyophilized powder
Synonym(s):
HGF Receptor (c-Met)
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About This Item
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biological source
human
Quality Level
recombinant
expressed in NSO cells
Assay
>95% (SDS-PAGE)
form
lyophilized powder
potency
0.1-5 ng/mL
mol wt
calculated mol wt 129 kDa
packaging
pkg of 100 μg
storage condition
avoid repeated freeze/thaw cycles
impurities
endotoxin, tested
UniProt accession no.
storage temp.
−20°C
Gene Information
human ... MET(4233)
Biochem/physiol Actions
Heterodimeric transmembrane glycoprotein with binding capacity for c-Met. Activation of this receptor has been correlated with induction of the Ras pathway.
Other Notes
Extracellular domain of c-Met fused to the C-terminal 6X histidine-tagged Fc region of human IgG1.
Physical form
Lyophilized from 0.2 μm filtered solution in phosphate buffered saline containing 5 mg bovine serum albumin.
Analysis Note
The biological activity is measured by its ability to bind human HGF.
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
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M Park et al.
Proceedings of the National Academy of Sciences of the United States of America, 84(18), 6379-6383 (1987-09-01)
We isolated overlapping cDNA clones corresponding to the major MET protooncogene transcript. The cDNA nucleotide sequence contained an open reading frame of 1408 amino acids with features characteristic of the tyrosine kinase family of growth factor receptors. These features include
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