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Key Documents

Do-11-10

85082301, from mouse unknown/unspecified

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About This Item

UNSPSC Code:
41106514

biological source

mouse unknown/unspecified

growth mode

Suspension

karyotype

Not specified

morphology

Not specified

products

Not specified

receptors

Not specified

relevant disease(s)

cancer

shipped in

dry ice

storage temp.

−196°C

Related Categories

Cell Line Origin

Mouse BALB/c (H-2d) T cells x Mouse AKR Thyoma, BW5147

Cell Line Description

Do-11-11 was produced by fusion of the antigen-specific I region-restricted (H-2d) BALB/c T-cell blasts with the AKR thyoma BW5147. This murine helper T cell hybridoma is specific for chicken ovalbumin (cOva) restricted to I-Ad and cross reacts with cOva I-antibody. The hybrid can be stimulated to secrete Interleukin 2 (IL-2) or to act as an antigen-specific helper T-cell. Expression of IL-2 can be lost by long-term culture of growth at high densities.

Culture Medium

DMEM or RPMI 1640 + 2 mM Glutamine + 10% Fetal Bovine Serum (FBS).

Subculture Routine

Maintain cultures between 3-9 x 100,000 cells/ml; 5% CO2; 37 °C. Cells should not be grown at high density; avoid long-term culture as this might lead to change of cell receptors.

Other Notes

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Certificates of Analysis (COA)

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