B6060

BVT.948

≥98% (HPLC), solid

• Synonym(s): 4-Hydroxy-3,3-dimethyl-2H-benzo[g]indole-2,5(3H)-dione
• Empirical Formula (Hill Notation): C₁₄H₁₁NO₃
• CAS Number: 39674-97-0
• Molecular Weight: 241.24
• MDL number: MFCD00616487
• UNSPSC Code: 12352200
• PubChem Substance ID: 24724422
• NACRES: NA.77

Properties

• Assay: ≥98% (HPLC)
• form: solid
• storage condition: desiccated; protect from light; under inert gas
• color: red
• solubility: DMSO: 18 mg/mL; H₂O: insoluble
• storage temp.: −20°C
• SMILES string: CC1(C)C(=O)N=C2c3ccccc3C(=O)C(O)=C12
• InChI: 1S/C14H11NO3/c1-14(2)9-10(15-13(14)18)7-5-3-4-6-8(7)11(16)12(9)17/h3-6,17H,1-2H3
• InChI key: BAQXWJQSUXZVIP-UHFFFAOYSA-N

Description

Biochem/physiol Actions

BVT.948 is a non-competitive inhibitor of protein tyrosine phosphatase (PTP). Enhances insulin signaling in cells and inhibits several cytochrome P450 isoforms in vitro.

Features and Benefits

BVT.948 is a non-competitive inhibitor of protein tyrosine phosphatase (PTP). Enhances insulin signaling in cells and inhibits several cytochrome P450 isoforms in vitro. Works through a different mechanism then the other PTP inhibitors. BVT.948 was able to enhance insulin signaling in cells, although it did not increase tyrosine phosphorylation globally. Furthermore, the compound was active in vivo, enhancing insulin tolerance tests in ob/ob mice, therefore apparently enhancing insulin sensitivity. BVT.948 was able to inhibit several other PTPs tested and also was efficient at inhibiting several cytochrome P450 isoforms in vitro.

Safety Information

• Pictograms: GHS07
• Signal Word: Warning
• Hazard Statements: H317
• Precautionary Statements: P261 - P272 - P280 - P302 + P352 - P333 + P313 - P362 + P364
• Hazard Classifications: Skin Sens. 1
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves