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D1685

Sigma-Aldrich

Docusate sodium

meets USP testing specifications

Synonym(s):

Docusate sodium salt, AOT, Bis(2-ethylhexyl) sulfosuccinate sodium salt, Sodium bis(2-ethylhexyl) sulfosuccinate, Sulfobutanedioic acid bis(2-ethylhexyl ester) sodium salt, Sulfosuccinic acid bis(2-ethylhexyl) ester sodium salt, ‘Dioctyl’ sulfosuccinate sodium salt

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About This Item

Empirical Formula (Hill Notation):
C20H37NaO7S
CAS Number:
577-11-7
Molecular Weight:
444.56
Beilstein:
4117588
EC Number:
209-406-4
MDL number:
MFCD00012455
UNSPSC Code:
12161902
PubChem Substance ID:
24893514
NACRES:
NA.21

Agency

meets USP testing specifications

Quality Level

200

description

anionic

Assay

99.0-100.5% anhydrous basis

form

solid

mol wt

444.56 g/mol

technique(s)

protein quantification: suitable

application(s)

detection
pharmaceutical (small molecule)

SMILES string

[Na+].CCCCC(CC)COC(=O)CC(C(=O)OCC(CC)CCCC)S([O-])(=O)=O

InChI

1S/C20H38O7S.Na/c1-5-9-11-16(7-3)14-26-19(21)13-18(28(23,24)25)20(22)27-15-17(8-4)12-10-6-2;/h16-18H,5-15H2,1-4H3,(H,23,24,25);/q;+1/p-1

InChI key

APSBXTVYXVQYAB-UHFFFAOYSA-M

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General description

Docusate sodium (sodium dioctylsulfosuccinate, DOSS) is commonly used as a surfactant, food additive and stool softener.

Application

Docusate sodium (DOSS, AOT) has been used in the preparation of the following:
  • Luminescent ceramics (phosphors).
  • Stock solution during the quantification of DOSS in sea food by using liquid chromatography tandem mass spectrometry (LC-MS/MS).
  • AOT-water-isooctane reverse micelle system
It has also been used in a study to understand its effect on protein bioactivity, when it is co-encapsulates with proteins in polymer based microsphere systems.
Forms reverse micelles in hydrocarbon solvents; Suitable for the solubilization of the major myelin transmembrane proteolipid

Pictograms

Corrosion
GHS05

Signal Word

Danger

Hazard Statements

H315,H318

Hazard Classifications

Eye Dam. 1 - Skin Irrit. 2

Storage Class Code

11 - Combustible Solids

WGK

WGK 2

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
0000055882
0000055882
MKCQ8061
MKCQ3985
MKCQ3986

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Determination of dioctylsulfosuccinate in select seafoods using a QuEChERS extraction with liquid chromatography-triple quadrupole mass spectrometry.
Boyd BL, et al.
Laboratory Information Bulletin (2010)
Preparation and characterization of rare-earth-doped Y2O3 luminescent ceramics by the use of reverse micelles.
Graeve OA and Corral JO.
Opt. Mater., 29(1), 24-30 (2006)
Protein bioactivity and polymer orientation is affected by stabilizer incorporation for double-walled microspheres.
Kokai LE, et al.
J. Controlled Release, 141(2), 168-176 (2010)
Nader Emami et al.
Journal of otolaryngology - head & neck surgery = Le Journal d'oto-rhino-laryngologie et de chirurgie cervico-faciale, 41(5), 316-319 (2012-10-25)
Docusate sodium (Colace) is an off-label ceruminolytic agent used to soften ear wax and relieve ear canal obstruction. At present, its effect on hearing in the presence of tympanic membrane (TM) perforation is not clear. The present study aimed to
Marc-Elie Nader et al.
Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery, 146(3), 455-460 (2011-11-22)
(1) To evaluate the ototoxic potential of docusate sodium and mineral oil and (2) to compare the cerumenolytic properties of these agents to water and a commercially available product. Prospective animal study. Docusate sodium and mineral oil are being used
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