AB15794
Anti-Dexras1 Antibody
Chemicon®, from rabbit
Synonym(s):
Activator of G-Protein Signaling 1, AGS1
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About This Item
UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41
biological source
rabbit
Quality Level
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
purified by
affinity chromatography
species reactivity
mouse
species reactivity (predicted by homology)
rat (100% immunogen homology), human (100% immunogen homology)
manufacturer/tradename
Chemicon®
technique(s)
western blot: suitable
NCBI accession no.
UniProt accession no.
shipped in
dry ice
target post-translational modification
unmodified
Gene Information
human ... RASD1(51655)
General description
Dexras1 is a member of the superfamily of RAS-g-proteins and directly binds to Gialpha heterotrimeric G-proteins where it appears to promote guanine nucleotide exchange on Gialpha. Dexras1 is implicated in NMDA receptor signaling through nitric oxide synthase.
Specificity
Dexras1 (Activator of G-Protein Signaling 1, AGS1). By Western blot the antibody recognizes a band at ~33 kDa on mouse brain extract. The antibody has also been used to detect Dexras1 in brown adipocyte lysate.
Other species have not been tested
Immunogen
Synthetic peptide.
Application
Research Category
Neuroscience
Neuroscience
Research Sub Category
Signaling Neuroscience
Signaling Neuroscience
This Anti-Dexras1 Antibody is validated for use in WB for the detection of Dexras1.
Western blot: 1:1,000 on mouse brain extract.
Optimal working dilutions must be determined by the end user.
Optimal working dilutions must be determined by the end user.
Physical form
ImmunoAffinity Purified
Liquid in PBS. Contains no preservative
Storage and Stability
6 months at -70°C from date of shipment
Legal Information
CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class Code
10 - Combustible liquids
WGK
WGK 2
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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M J Cismowski et al.
The Journal of biological chemistry, 275(31), 23421-23424 (2000-06-07)
Utilizing a functional screen in the yeast Saccharomyces cerevisiae we identified mammalian proteins that activate heterotrimeric G-protein signaling pathways in a receptor-independent fashion. One of the identified activators, termed AGS1 (for activator of G-protein signaling), is a human Ras-related G-protein
T E Graham et al.
Endocrinology, 142(6), 2631-2640 (2001-05-18)
Dexras1 is a novel GTP-binding protein that shares structural similarity with the Ras family of small molecular weight GTPases and is strongly and rapidly induced during treatment with dexamethasone. The function of Dexras1 and its contribution to glucocorticoid-dependent signaling in
M J Cismowski et al.
Nature biotechnology, 17(9), 878-883 (1999-09-03)
We describe genetic screens in Saccharomyces cerevisiae designed to identify mammalian nonreceptor modulators of G-protein signaling pathways. Strains lacking a pheromone-responsive G-protein coupled receptor and expressing a mammalian-yeast Galpha hybrid protein were made conditional for growth upon either pheromone pathway
Ras dexamethasone-induced protein 1 is a modulator of hormone secretion in the volume overloaded heart.
McGrath, MF; Ogawa, T; de Bold, AJ
American Journal of Physiology. Heart and Circulatory Physiology null
M Fang et al.
Neuron, 28(1), 183-193 (2000-11-22)
Because nitric oxide (NO) is a highly reactive signaling molecule, chemical inactivation by reaction with oxygen, superoxide, and glutathione competes with specific interactions with target proteins. NO signaling may be enhanced by adaptor proteins that couple neuronal NO synthase (nNOS)
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