219419

Cathepsin Inhibitor III

The Cathepsin Inhibitor III controls the biological activity of Cathepsin. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.

• Synonym(s): Cathepsin Inhibitor III, Z-FG-NHO-BzOME
• Empirical Formula (Hill Notation): C₂₇H₂₇N₃O₇
• Molecular Weight: 505.52
• UNSPSC Code: 12352200

Properties

• Quality Level: 100
• Assay: >90% (HPLC)
• form: solid
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze; desiccated; protect from light
• color: white
• solubility: ethanol: 1 mg/mL; DMSO: 5 mg/mL
• shipped in: ambient
• storage temp.: 10-30°C

Description

General description

Cysteine protease inhibitor. Selectively inhibits cathepsin B (k₂/K_i = 1 x 10⁴ M^-1 sec^-1), cathepsin L (k₂/K_i = 1.5 x 10⁵ M^-1 sec^-1), cathepsin S (k₂/K_i = 6.6 x 10⁴ M^-1 sec^-1), and papain (k₂/K_i = 1 x 10³ M^-1 sec^-1).

Cysteine protease inhibitor. Selectively inhibits cathepsin B (k₂/K_i = 1.0 x 10⁴ M^-1sec^-1), cathepsin L (k₂/K_i = 1.5 x 10⁵ M^-1sec^-1), cathepsin S (k₂/Ki = 6.6 x 10⁴ M^-1sec^-1), and papain (k₂/K_i = 1.0 x 10³ M^-1sec^-1). Half-life in buffered solution (pH 5-9) = 37 h (30°C); 300 h (0°C).

Half-life in buffered solution (pH 5-9) = 37 h (30°C); 300 h (0°C).

Biochem/physiol Actions

Cell permeable: no

Primary Target
cathepsin B

Product does not compete with ATP.

Reversible: no

k₂/K_i = 1 x 10⁴ M⁻¹ sec⁻¹

Warning

Toxicity: Standard Handling (A)

Sequence

Z-Phe-Gly-NHO-Bz-pOMe

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Demuth, H.-U., et al. 1996. Biochim. Biophys. Acta1295, 179.
Brömme, D., and Demuth, H.-U. 1994. Methods Enzymol. 244, 671.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 1
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable