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1.15640

Sigma-Aldrich

Aldehyde dehydrogenase

lyophilized, from yeast, pkg of 100 units/vial

Synonym(s):

Aldehyde dehydrogenase

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About This Item

CAS Number:
MDL number:
UNSPSC Code:
12352204
EC Index Number:
232-846-3
NACRES:
NA.21

biological source

yeast

Quality Level

form

lyophilized

specific activity

≥15 U/mg (calculated on the protein content)

packaging

pkg of 100 units/vial

storage temp.

2-8°C

General description

Aldehyde dehydrogenases (ALDH) form a superfamily of phase-I oxidases and are evolutionarily conserved in eubacteria, eukaryotes, archaea, and other living organisms. ALDH is abundantly expressed in the liver and found in hepatic tissue. They are localized to the cytoplasm, mitochondria, endoplasmic reticulum, and nucleus.

Biochem/physiol Actions

Aldehyde dehydrogenases (ALDH) metabolize endogenous and exogenous reactive compounds to maintain cellular homeostasis. This group of enzymes catalyzes the NADP+-dependent irreversible oxidation of aldehydes to form carboxylic acids. ALDH isozymes have broad substrate specificity. Inactivation of ALDH causes cytotoxicity due to substrate accumulation.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


Certificates of Analysis (COA)

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Endogenous Mitochondrial Aldehyde Dehydrogenase-2 as an Antioxidan
Patel VB, et al.
Liver, 247-259 (2018)

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