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Merck
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Key Documents

07-728

Sigma-Aldrich

Anti-HRI Antibody

serum, Upstate®

Synonym(s):

Anti-HCR, Anti-HRI, Anti-LEMSPAD, Anti-hHRI

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About This Item

UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41

biological source

rabbit

Quality Level

100

antibody form

serum

antibody product type

primary antibodies

clone

polyclonal

species reactivity

rabbit, human, mouse

manufacturer/tradename

Upstate®

technique(s)

immunoprecipitation (IP): suitable
western blot: suitable

isotype

IgG

NCBI accession no.

NM_014413.2

UniProt accession no.

Q9BQI3

shipped in

dry ice

target post-translational modification

unmodified

Gene Information

human ... EIF2AK1(27102)
mouse ... Eif2Ak1(15467)

Specificity

HRI

Immunogen

6His-tagged fusion protein corres-ponding to residues 1-138 of mouse heme-regulated inhibitor (HRI)

Application

Detect HRI using this Anti-HRI Antibody validated for use in IP & WB.

Quality

Routinely evaluated by immunoblot on lysates from mouse reticulocytes.

Target description

72kDa

Legal Information

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

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Storage Class Code

12 - Non Combustible Liquids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Maryam Rafie-Kolpin et al.
Biochemistry, 42(21), 6536-6544 (2003-05-28)
In heme deficiency, protein synthesis is inhibited by the activation of the heme-regulated eIF2alpha kinase (HRI) through its multiple autophosphorylation. Autophosphorylation sites in HRI were identified in order to investigate their functions. We found that there were eight major tryptic
Visibly stressed: the role of eIF2, TIA-1, and stress granules in protein translation.
Anderson, Paul and Kedersha, Nancy
Cell Stress & Chaperones, 7, 213-221 (2002)
Takahiro Sakai et al.
Antioxidants (Basel, Switzerland), 10(9) (2021-09-29)
Lung fibrosis is the primary pathology in idiopathic pulmonary fibrosis and is considered to result from an increase in reactive oxygen species (ROS) levels in alveolar epithelial cells. However, the exact mechanism underlying lung fibrosis remains unclear and there is
The eIF-2alpha kinases and the control of protein synthesis.
de Haro, C, et al.
Faseb Journal, 10, 1378-1387 (1996)
J J Chen et al.
Trends in biochemical sciences, 20(3), 105-108 (1995-03-01)
Protein synthesis is regulated by the phosphorylation of the alpha-subunit of eukaryotic initiation factor 2 (eIF-2 alpha) in a variety of cells. At present, there are two distinct mammalian eIF-2 alpha kinases that have been cloned, the double-stranded-RNA-dependent eIF-2 alpha
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