P-909

Acetaminophen-D₄ solution

100 μg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant^®

• Empirical Formula (Hill Notation): C₈D₄H₅NO₂
• CAS Number: 64315-36-2
• Molecular Weight: 155.19
• EC Number: 200-659-6
• UNSPSC Code: 41116107
• NACRES: NA.24

Properties

• grade: certified reference material
• form: liquid
• feature: Snap-N-Spike^®/Snap-N-Shoot^®
• packaging: ampule of 1 mL
• manufacturer/tradename: Cerilliant^®
• concentration: 100 μg/mL in methanol
• technique(s): gas chromatography (GC): suitable; liquid chromatography (LC): suitable
• application(s): forensics and toxicology
• format: single component solution
• storage temp.: −20°C
• SMILES string: [2H]c1c([2H])c(NC(C)=O)c([2H])c([2H])c1O
• InChI: 1S/C8H9NO2/c1-6(10)9-7-2-4-8(11)5-3-7/h2-5,11H,1H3,(H,9,10)/i2D,3D,4D,5D
• InChI key: RZVAJINKPMORJF-QFFDRWTDSA-N

Description

General description

A stable-labeled internal standard suitable for quantitation of acetaminophen levels in urine, serum, or plasma by LC/MS or GC/MS for clinical toxicology, isotope dilution methods, P450 studies, and other pharmaceutical research. Acetaminophen, or Paracetamol, is a common over-the-counter COX inhibitor drug used for pain relief and fever reduction.

Application

• Simultaneous determination of acetaminophen and oxycoDonein human plasma by LC-MS/MS and its application to a pharmacokinetic study: Highlights the application of acetaminophen-D₄ as an internal standard in pharmacokinetic studies to ensure accurate measurement of drug levels in plasma, crucial for drug development and therapeutic monitoring (Lu et al., 2018).


• Simultaneous quantification of acetaminophen and five acetaminophen metabolites in human plasma and urine by high-performance liquid chromatography-electrospray ionization-tandem mass spectrometry: Demonstrates the use of acetaminophen-D₄ in complex bioanalytical methods for studying drug metabolism and excretion in clinical pharmacology (Cook et al., 2015).


• Application of high-performance liquid chromatography/chemical reaction interface mass spectrometry for the analysis of conjugated metabolites: Discusses a method using deuterated acetaminophen (such as acetaminophen-D₄) to analyze conjugated drug metabolites, enhancing the understanding of drug metabolism pathways (Teffera and Abramson, 1994).


• Acetaminophen production in man after coadministration of acetanilid and phenacetin: A study that possibly uses deuterated compounds like acetaminophen-D₄ to trace metabolic pathways and interactions between multiple analgesics, providing insights into their pharmacokinetic behaviors (Baty and Robinson, 1977).

Legal Information

CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany

Snap-N-Shoot is a registered trademark of Cerilliant Corporation

Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany

Safety Information

• Pictograms: GHS02,GHS06,GHS08
• Signal Word: Danger
• Hazard Statements: H225,H301 + H311 + H331,H370
• Precautionary Statements: P210 - P280 - P301 + P310 + P330 - P302 + P352 + P312 - P304 + P340 + P311
• Hazard Classifications: Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1
• Target Organs: Eyes
• Storage Class Code: 3 - Flammable liquids
• WGK: WGK 1
• Flash Point(F): 49.5 °F - closed cup
• Flash Point(C): 9.7 °C - closed cup