934283

4-(Aminoethyl)-1-N-Boc-piperidine

≥95.0%

• Synonym(s): 1-tert-Butoxycarbonyl-4-piperidineethanamine, 2-(N-tert-Butoxycarbonyl-4-piperidinyl)ethylamine
• Empirical Formula (Hill Notation): C₁₂H₂₄N₂O₂
• CAS Number: 146093-46-1
• Molecular Weight: 228.33
• MDL number: MFCD04038459
• UNSPSC Code: 12352200
• NACRES: NA.21

Properties

• Quality Level: 100
• Assay: ≥95.0%
• form: semisolid
• color: off-white to light yellow
• storage temp.: 2-8°C
• SMILES string: O=C(OC(C)(C)C)N1CCC(CCN)CC1

Description

Application

A semi-flexible linker useful for PROTAC development for targeted protein degradation. Incorporation of rigidity into the linker region of PROTACs may impact degradation kinetics as well as drug design (absorption; distribution; metabolism; excretion; and toxicity; ADMET) properties of PROTACs.

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Other Notes

Targeted Protein Degradation by Small Molecules

Destruction of DNA-Binding Proteins by Programmable Oligonucleotide PROTAC (O′PROTAC): Effective Targeting of LEF1 and ERG

Small-Molecule PROTACS: New Approaches to Protein Degradation

Targeted Protein Degradation: from Chemical Biology to Drug Discovery

Impact of linker length on the activity of PROTACs

Legal Information

PROTAC^® is a registered trademark of Arvinas Operations; Inc.; and is used under license.

PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license

Safety Information

• Pictograms: GHS07
• Signal Word: Warning
• Hazard Statements: H302
• Precautionary Statements: P264 - P270 - P301 + P312 - P501
• Hazard Classifications: Acute Tox. 4 Oral
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable