751855

Hydrazine solution

1 M in acetonitrile

• Synonym(s): Hydrazine, Nitrogen hydride
• Linear Formula: NH₂NH₂
• CAS Number: 302-01-2
• Molecular Weight: 32.05
• Beilstein: 878137
• MDL number: MFCD00011417
• UNSPSC Code: 12352100
• PubChem Substance ID: 329766244
• NACRES: NA.22

Properties

• form: liquid
• concentration: 1 M in acetonitrile
• refractive index: n20/D 1.348
• density: 0.779 g/mL at 25 °C
• SMILES string: NN
• InChI: 1S/H4N2/c1-2/h1-2H2
• InChI key: OAKJQQAXSVQMHS-UHFFFAOYSA-N

Description

General description

Hydrazine (N₂H₄) solution is a common reducing agent and a versatile reagent in organic synthesis. It can reduce a variety of functional groups like ketones, aldehydes, imines, nitro compounds, azides & nitrates to their corresponding amines. It also serves as a source of nitrogen in the synthesis of heterocyclic compounds, such as pyrazoles and pyrazolines.

Application

Hydrazine solution (in acetonitrile) can be used as a reducing source for the reduction of carbon-carbon multiple bonds in alkenes, alkynes, and α,β-unsaturated esters using metal-organic frameworks (MOFs) as heterogeneous catalysts. It is also used in the synthesis of polysubstituted 2-aminoimidazoles from 2-aminopyrimidines and α-bromocarbonyl compounds.

Safety Information

• Pictograms: GHS02,GHS06,GHS08,GHS09
• Signal Word: Danger
• Hazard Statements: H225,H302 + H312,H315,H317,H319,H331,H350,H411
• Precautionary Statements: P210 - P273 - P280 - P303 + P361 + P353 - P304 + P340 + P311 - P308 + P313
• Hazard Classifications: Acute Tox. 3 Inhalation - Acute Tox. 4 Dermal - Acute Tox. 4 Oral - Aquatic Chronic 2 - Carc. 1B - Eye Irrit. 2 - Flam. Liq. 2 - Skin Irrit. 2 - Skin Sens. 1
• Storage Class Code: 3 - Flammable liquids
• WGK: WGK 3
• Flash Point(F): 41.0 °F
• Flash Point(C): 5 °C