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Sigma-Aldrich

Poly(styrene)-block-poly(acrylic acid)

PS:PAA 30,000:2,000, PDI ≤1.1

Synonym(s):

PS-PAA, PS-PAA amphiphilic diblock copolymer

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About This Item

Linear Formula:
C4H6N(C8H8)x(C3H4O2)yH
UNSPSC Code:
12352100
NACRES:
NA.23

form

powder

mol wt

Mn 1,000-2,000 (poly(acrylic acid))
Mn 27,000-31,000 (polystyrene)
Mn 28,000-33,000 (total)

PDI

≤1.1

Application

Polystyrene-block-polyacrylic acid is a diblock copolymer used for making polymeric micelles/ vesicles (polymersomes) and other encapsulation applications, . This PS-block-PAA copolymer is 10 wt. % PAA; and should form micelles in water in the 100~200 nm range. The polystyrene degree of polymerization (DP) is 275 and the polyacrylic acid DP is 30.

Legal Information

Sold for research purposes only and subject to field restriction: see www.sigmaaldrich.com/raftlicense. Patents: 7,714,075; 7,250,479; 7,666,962; 6,642,318; 6,747,111; W2010/8356.

Pictograms

Exclamation mark

Signal Word

Warning

Hazard Statements

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Target Organs

Respiratory system

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


Certificates of Analysis (COA)

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Kaoutar Moumile et al.
Journal of clinical microbiology, 42(2), 923-924 (2004-02-10)
We describe a case of primary purulent culture-negative pericarditis caused by Neisseria meningitidis serogroup C occurring in an 8-month-old previously healthy boy, which was detected in pericardial fluid by broad-spectrum PCR amplification.
Dennis E Discher et al.
Science (New York, N.Y.), 297(5583), 967-973 (2002-08-10)
Vesicles are microscopic sacs that enclose a volume with a molecularly thin membrane. The membranes are generally self-directed assemblies of amphiphilic molecules with a dual hydrophilic-hydrophobic character. Biological amphiphiles form vesicles central to cell function and are principally lipids of

Articles

Reversible addition–fragmentation chain transfer (RAFT) polymerization is rapidly moving to the forefront in construction of drug and gene delivery vehicles.

Over the past two decades, the rapid advance of controlled living polymerization (CLP) techniques.

The development of drugs that target specific locations within the human body remains one of the greatest challenges in biomedicine today.

Wide range of functional polymers for biomedical applications have been synthesized and structurally characterized. Several classes of polymers including biodegradable polymers, hydrophilic & amphiphilic polymers, and stimuli responsive polymers have been prepared using controlled and directed functionalization via "living" polymerization such as RAFT, ionic and ring opening polymerization. Selected polymers have been studied for their structure-properties relationship. "

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