540838

4-Piperidine butyric acid hydrochloride

97%

• Synonym(s): 4-(Piperidin-4-yl)butanoic acid hydrochloride
• Empirical Formula (Hill Notation): C₉H₁₈ClNO₂
• CAS Number: 84512-08-3
• Molecular Weight: 207.70
• MDL number: MFCD02684340
• UNSPSC Code: 12352100
• PubChem Substance ID: 24878498
• NACRES: NA.22

Properties

• Assay: 97%
• mp: 113-117 °C (lit.)
• SMILES string: Cl[H].OC(=O)CCCC1CCNCC1
• InChI: 1S/C9H17NO2.ClH/c11-9(12)3-1-2-8-4-6-10-7-5-8;/h8,10H,1-7H2,(H,11,12);1H
• InChI key: UTPNREIRALGKPW-UHFFFAOYSA-N

Description

General description

4-Piperidine butyric acid hydrochloride participates in the synthesis of FK866 [(E)-N-[4-(1-benzoylpiperidin-4-yl)butyl]-3-(pyridin-3-yl)acrylamide], an inhibitor of NAD biosynthesis.

Application

Reactant for:
Modification of 3-amidinophenylalanine-derived matriptase inhibitors
Reactions between Weinreb amides and 2-magnesiated oxazoles

Reactant for synthesis of:
NAmPRTase inhibitors
FK866 analogs for NAD salvage inhibition

Safety Information

• Pictograms: GHS07
• Signal Word: Warning
• Hazard Statements: H302,H315,H319,H335
• Precautionary Statements: P261 - P264 - P271 - P301 + P312 - P302 + P352 - P305 + P351 + P338
• Hazard Classifications: Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• Target Organs: Respiratory system
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 2
• Flash Point(F): 210.2 °F - closed cup
• Flash Point(C): 99 °C - closed cup
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves