255165
Tributylmethylammonium chloride solution
75 wt. % in H2O
Synonym(s):
Methyltributylammonium chloride solution
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About This Item
Linear Formula:
CH3N[CH3(CH2)3]3Cl
CAS Number:
Molecular Weight:
235.84
MDL number:
UNSPSC Code:
12352116
PubChem Substance ID:
NACRES:
NA.22
Recommended Products
vapor pressure
7.9 mmHg ( 25 °C)
concentration
75 wt. % in H2O
refractive index
n20/D 1.4682
bp
152 °C
density
0.964 g/mL at 25 °C
SMILES string
[Cl-].CCCC[N+](C)(CCCC)CCCC
InChI
1S/C13H30N.ClH/c1-5-8-11-14(4,12-9-6-2)13-10-7-3;/h5-13H2,1-4H3;1H/q+1;/p-1
InChI key
IPILPUZVTYHGIL-UHFFFAOYSA-M
General description
Tributylmethylammonium chloride (TBMAC) is a quaternary ammonium salt commonly used as a phase-transfer catalyst in various organic synthesis reactions. It can also be used in the preparation of ionic liquids.
Application
Tributylmethylammonium chloride solution is used as a phase transfer catalyst in the synthesis of ɛ-caprolactone by Baeyer-Villiger oxidation of cyclohexanone in the presence of KHSO5 as an oxidizing agent.
Signal Word
Warning
Hazard Statements
Precautionary Statements
Hazard Classifications
Acute Tox. 4 Dermal - Aquatic Chronic 2 - Eye Irrit. 2 - Skin Irrit. 2
Storage Class Code
10 - Combustible liquids
WGK
WGK 2
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
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Min-Koo Choi et al.
Journal of pharmaceutical sciences, 94(2), 317-326 (2004-12-01)
The in vivo canalicular excretion clearance of tributylmethyl ammonium (TBuMA), a P-glycoprotein (P-gp) substrate, was previously reported to be unaffected by the induction of an experimental hepatic injury (EHI) by CCl(4) despite the increased expression of P-gp in the EHI
J W Smit et al.
British journal of pharmacology, 123(3), 361-370 (1998-03-21)
1. In the present study it was tested whether known P-glycoprotein (P-gp) substrates/MDR reversal agents interact with small (type 1) and bulky (type 2) cationic drugs at the level of biliary excretion in the rat isolated perfused liver model (IPRL).
J E van Montfoort et al.
The Journal of pharmacology and experimental therapeutics, 298(1), 110-115 (2001-06-16)
Previous inhibition studies with taurocholate and cardiac glycosides suggested the presence of separate uptake systems for small "type I" (system1) and for bulky "type II" (system2) organic cations in rat hepatocytes. To identify the transport systems involved in type I
Soon-Sun Hong et al.
Archives of pharmacal research, 29(4), 323-327 (2006-05-10)
The objective of this study was to examine the pharmacokinetics of organic cations in intrahepatic cholestatic rats. A pretreatment with 17alpha-ethynylestradiol was used to induce intrahepatic cholestasis, and tributylmethylammonium (TBuMA) was used as a representative model organic cation. When [3H]TBuMA
Soon-Sun Hong et al.
Archives of pharmacal research, 29(4), 318-322 (2006-05-10)
Many quaternary ammonium salts are incompletely absorbed after their oral administration and may also be actively secreted into the intestine. However, the underlying mechanism(s) that control the transport of these cations across the intestinal epithelium is not well understood. In
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