222569

Fomepizole

99%

• Synonym(s): 4-Methylpyrazole
• Empirical Formula (Hill Notation): C₄H₆N₂
• CAS Number: 7554-65-6
• Molecular Weight: 82.10
• Beilstein: 105204
• EC Number: 231-445-0
• MDL number: MFCD00005245
• UNSPSC Code: 12352100
• PubChem Substance ID: 24853343
• NACRES: NA.22

Properties

• Assay: 99%
• refractive index: n20/D 1.495 (lit.)
• bp: 99-100 °C/6 mmHg (lit.)
• solubility: alcohol: soluble(lit.); water: soluble(lit.)
• density: 0.993 g/mL at 25 °C (lit.)
• SMILES string: Cc1cn[nH]c1
• InChI: 1S/C4H6N2/c1-4-2-5-6-3-4/h2-3H,1H3,(H,5,6)
• InChI key: RIKMMFOAQPJVMX-UHFFFAOYSA-N
• Gene Information: human ... ADH1A(124) , ADH1B(125) , ADH1C(126)

Description

General description

4-Methylpyrazole inhibits CYP2E1 activity. It also acts as alcohol dehydrogenase inhibitor.

Application

Fomepizole (4-Methylpyrazole) can be used as:

• A reactant to prepare 4-methyl-1-phenyl-1H-pyrazole by reacting with bromobenzene via N-arylation using a copper catalyst.
• A starting material for the synthesis of 4-methyl-3(5)-nitropyrazole by nitration.
• A ligand in the preparation of gallium(III) complex of 4-methylpyrazole as potential antitumor and antiviral agent.

Useful as an antidote in methanol and ethylene glycol poisoning.

Biochem/physiol Actions

Alcohol dehydrogenase inhibitor

Alcohol dehydrogenase inhibitor.

Safety Information

• Pictograms: GHS07
• Signal Word: Warning
• Hazard Statements: H302 - H315 - H319 - H335
• Precautionary Statements: P261 - P264 - P271 - P301 + P312 - P302 + P352 - P305 + P351 + P338
• Hazard Classifications: Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• Target Organs: Respiratory system
• Storage Class Code: 10 - Combustible liquids
• WGK: WGK 3
• Flash Point(F): 204.8 °F - closed cup
• Flash Point(C): 96 °C - closed cup
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves