Z0878

Zaprinast

solid

• Synonym(s): 1,4-Dihydro-5-(2-propoxyphenyl)-7H-1,2,3-triazolo(4,5-d)pyrimidin-7-one
• Empirical Formula (Hill Notation): C₁₃H₁₃N₅O₂
• CAS Number: 37762-06-4
• Molecular Weight: 271.27
• EC Number: 253-655-1
• MDL number: MFCD00214073
• UNSPSC Code: 12352202
• PubChem Substance ID: 24278072
• NACRES: NA.77

Properties

• form: solid
• Quality Level: 200
• color: white
• solubility: 45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: 0.11 mg/mL; DMSO: 10 mg/mL; H₂O: insoluble
• SMILES string: CCCOc1ccccc1C2=NC(=O)c3nn[nH]c3N2
• InChI: 1S/C13H13N5O2/c1-2-7-20-9-6-4-3-5-8(9)11-14-12-10(13(19)15-11)16-18-17-12/h3-6H,2,7H2,1H3,(H2,14,15,16,17,18,19)
• InChI key: REZGGXNDEMKIQB-UHFFFAOYSA-N
• Gene Information: human ... PDE2A(5138) , PDE4A(5141) , PDE4B(5142) , PDE4D(5144)

Description

Application

Zaprinast has been used to determine its inhibitory effect on the meiosis of oocytes by germinal vesicle breakdown (GVBD) assay and to test the inhibitory effect of it on the retinal cells by immunohistochemistry.

Biochem/physiol Actions

Zaprinast insubstantially inhibits phosphodiesterase 10 and 11 (PDE10 and PDE11). It also exhibits vasodilating effects.

Selective inhibitor of cGMP-specific phosphodiesterases V and VI (PDE5/6) and an agonist at the G protein-coupled receptor 35 (GPR35).

Safety Information

• Pictograms: GHS07
• Signal Word: Warning
• Hazard Statements: H315,H319,H335
• Precautionary Statements: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• Hazard Classifications: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• Target Organs: Respiratory system
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves