Z0167

Zearalanone

• Synonym(s): 2,4-Dihydroxy-6-(10-hydroxy-6-oxoundecyl)benzoic acid μ-lactone
• Empirical Formula (Hill Notation): C₁₈H₂₄O₅
• CAS Number: 5975-78-0
• Molecular Weight: 320.38
• MDL number: MFCD00135821
• UNSPSC Code: 12352200
• PubChem Substance ID: 24902160
• NACRES: NA.77

Properties

• sterility: non-sterile
• Quality Level: 200
• Assay: ≥98% (TLC)
• form: powder
• solubility: methanol: 9.80-10.20 mg/mL, clear, colorless
• shipped in: ambient
• storage temp.: −20°C
• SMILES string: C[C@H]1CCCC(=O)CCCCCc2cc(O)cc(O)c2C(=O)O1
• InChI: 1S/C18H24O5/c1-12-6-5-9-14(19)8-4-2-3-7-13-10-15(20)11-16(21)17(13)18(22)23-12/h10-12,20-21H,2-9H2,1H3/t12-/m0/s1
• InChI key: APJDQUGPCJRQRJ-LBPRGKRZSA-N
• Gene Information: rat ... Ar(24208)

Description

General description

Zearalanone (ZEA) or F-2 toxin, a nonsteroidal estrogenic mycotoxin is produced by various Fusarium species. Fusarium graminearum is considered as the primary producer of zearalanone. It is usually seen in moldy hay, high-moisture corn, corn infected before harvest etc.

Application

Zearalanone has been used:

• as mycotoxin to study its effects on the histology of ovaries in pre-pubertal bitches
• as a mycotoxin to investigate its influence on selected immunological, haematological and biochemical indexes in bitches
• as a standard to develop calibration curves in order to study its effects on progesterone and 17β-estradiol concentrations in peripheral blood and body weights of pre-pubertal female Beagle dogs
• as a standard to develop calibration curves to study its level of intoxication in women with neoplastic lesions in the reproductive tract

Biochem/physiol Actions

Zearalanone is believed to cause vulvovaginitis and estrogenic responses in swine.

Safety Information

• Pictograms: GHS08,GHS07
• Signal Word: Warning
• Hazard Statements: H302 + H312 + H332,H315,H319,H335,H351
• Precautionary Statements: P280 - P301 + P312 - P302 + P352 + P312 - P304 + P340 + P312 - P305 + P351 + P338 - P308 + P313
• Hazard Classifications: Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Carc. 2 - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• Target Organs: Respiratory system
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves