SML3747

IM1761092 hydrochloride

≥98% (HPLC)

• Synonym(s): IM 1092 hydrochloride, IM 1761092 hydrochloride, IM-1092 hydrochloride, IM-1761092 hydrochloride, IM1092 hydrochloride, N-1-(3-chloro-4-iodo)phenethylbiguanide hydrochloride
• Empirical Formula (Hill Notation): C₁₀H₁₃ClIN₅·HCl
• CAS Number: 1820014-33-2
• Molecular Weight: 402.06
• UNSPSC Code: 12352200
• NACRES: NA.21

Properties

• Quality Level: 100
• Assay: ≥98% (HPLC)
• form: powder
• storage condition: desiccated
• color: white to beige
• solubility: H₂O: 2 mg/mL, clear
• storage temp.: room temp
• SMILES string: ClC1=CC(CCNC(NC(N)=N)=N)=CC=C1I.Cl

Description

Biochem/physiol Actions

IM1761092 (IM1092) is a biguanide-based mammalian respiratory complex I inhibitor that reduces cellular oxygen consumption (IC50 = 3.6 μM post 6h treatment; HEPG2 C3A cells) and exhibits significantly higher potency than metformin and phenformin (by 10- to 2000-fold depending on the conditions) using bovine heart mitochondrial membrane preparations (IM1092/phenformin/metformin IC50 = 32 μM/3.8 mM/99 mM against active complex I, 4 μM/131 μM/33 mM against deactive complex I).

Caution

Hygroscopic

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable