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SML2947

Sigma-Aldrich

Penehyclidine hydrochloride

≥98% (HPLC)

Synonym(s):

α-[(1-Azabicyclo[2.2.2]oct-3-yloxy)methyl]-α-cyclopentyl-benzenemethanol hydrochloride, 3-(2′-phenyl-2′-cyclopentyl-2′-hydroxyl-ethoxy) quinuclidine, Penequine hydrochloride, Penequinine

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About This Item

Empirical Formula (Hill Notation):
C20H29NO2 · HCl
CAS Number:
151937-76-7
Molecular Weight:
351.91
MDL number:
MFCD11040804
UNSPSC Code:
12352200
NACRES:
NA.77

Quality Level

100

Assay

≥98% (HPLC)

form

powder (hygroscopic)

storage condition

desiccated

color

white to beige

solubility

H2O: 2 mg/mL, clear

storage temp.

−20°C

InChI

1S/C20H29NO2.ClH/c22-20(18-8-4-5-9-18,17-6-2-1-3-7-17)15-23-19-14-21-12-10-16(19)11-13-21;/h1-3,6-7,16,18-19,22H,4-5,8-15H2;1H

InChI key

DDTVVMRZNVIVQM-UHFFFAOYSA-N

Biochem/physiol Actions

Penehyclidine hydrochloride is a brain penetrant anticholinergic drug that exhibits both antimuscarinic and antinicotinic activity. Penehyclidine hydrochloride does not induce muscarinic 2 receptor-associated cardiovascular side effects. Penehyclidine hydrochloride is effective in experimental models of heart, lung and brain ischemia reperfusion injury.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Yong-An Wang et al.
Life sciences, 78(2), 210-223 (2005-09-13)
Previous studies have paid little attention to the anticonvulsant effect of anticholinergic drugs that act on both muscarinic (M) and nicotinic (N) receptors during soman-induced seizures. Therefore, with the establishment of a soman-induced seizures model in rats, this study evaluated

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