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SML1462

Sigma-Aldrich

Practolol

≥95% (HPLC)

Synonym(s):

(±)-Practolol, 1-(4-Acetamidophenoxy)-3-isopropylamino-2-propanol, 4′-[2-Hydroxy-3-(isopropylamino)propoxy]acetanilidex, AY 21011, Dalzic, ICI 50172, N-[4-[2-Hydroxy-3-[(1-methylethyl)amino]propoxy]phenyl]acetamide

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About This Item

Empirical Formula (Hill Notation):
C14H22N2O3
CAS Number:
6673-35-4
Molecular Weight:
266.34
EC Number:
229-712-1
MDL number:
MFCD00864573
UNSPSC Code:
12352200
PubChem Substance ID:
329825896
NACRES:
NA.77

Quality Level

100

Assay

≥95% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 15 mg/mL, clear

storage temp.

2-8°C

SMILES string

CC(NC1=CC=C(OCC(O)CNC(C)C)C=C1)=O

InChI

1S/C14H22N2O3/c1-10(2)15-8-13(18)9-19-14-6-4-12(5-7-14)16-11(3)17/h4-7,10,13,15,18H,8-9H2,1-3H3,(H,16,17)

InChI key

DURULFYMVIFBIR-UHFFFAOYSA-N

Biochem/physiol Actions

Practolol is a potent and selective β-adrenoceptor antagonist. Practolol is a beta blocker that was discontinued to due to adverse reactions (keratoconjunctivitis sicca, conjunctival scarring, fibrosis, metaplasia, and shrinkage).

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Jian-Qiao Cheng et al.
Molecules (Basel, Switzerland), 24(4) (2019-03-03)
This paper presents an application of high performance liquid chromatography coupled with quadrupole orbitrap high-resolution mass spectrometry (HPLC-Q-Orbitrap HRMS) for the analysis of 27 β-blockers and metabolites in milk powder. Homogenized milk power samples were extracted by acetonitrile and purified
Guohua Huang et al.
Combinatorial chemistry & high throughput screening, 19(2), 121-128 (2015-11-11)
It is crucial to identify the molecular targets of a compound during the course of the new drug discovery and drug development. Due to the complexity of biological systems, finding drug targets by biological experiments is very tedious and expensive.

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