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SML1044

Sigma-Aldrich

Zosuquidar hydrochloride

≥98% (HPLC), powder, p-Glycoprotein inhibitor

Synonym(s):

(2R)-Anti-5-[3-[4-(10,11-difluoromethanodibenzosuber-5-yl)piperazin-1-yl]-2-hydroxypropoxy]quinoline hydrochloride, LY-335979, RS-33295-198

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About This Item

Empirical Formula (Hill Notation):
C32H31F2N3O2 · xHCl
CAS Number:
167354-41-8
Molecular Weight:
527.60 (free base basis)
UNSPSC Code:
12161501
PubChem Substance ID:
329825638
NACRES:
NA.77

product name

Zosuquidar hydrochloride, ≥98% (HPLC)

Assay

≥98% (HPLC)

form

powder

storage condition

desiccated

color

white to beige

solubility

H2O: 4 mg/mL, clear (warmed)

storage temp.

−20°C

SMILES string

O[C@@H](COC1=C(C=CC=N2)C2=CC=C1)CN(CC3)CCN3[C@@H]4C5=C(C=CC=C5)[C@@H]6[C@@H](C6(F)F)C7=C4C=CC=C7.Cl

InChI

1S/C32H31F2N3O2.ClH/c33-32(34)29-22-7-1-3-9-24(22)31(25-10-4-2-8-23(25)30(29)32)37-17-15-36(16-18-37)19-21(38)20-39-28-13-5-12-27-26(28)11-6-14-35-27;/h1-14,21,29-31,38H,15-20H2;1H/t21-,29-,30+,31-;/m1./s1

InChI key

VQJFFWJUYDGTQZ-FCNWNIDBSA-N

Biochem/physiol Actions

Zosuqidar is a potent inhibitor of P-glycoprotein (P-gp, MDR1) a transporter protein that is a key modulator of cellular drug efflux. Zosuquidar sensitizes AML, and other cancer cell lines to cytotoxic drugs.

Features and Benefits

This compound is a featured product for ADME Tox research. Click here to discover more featured ADME Tox products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H315,H319,H335

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Target Organs

Respiratory system

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Yoko Nagaya et al.
Drug metabolism and disposition: the biological fate of chemicals, 48(11), 1183-1190 (2020-08-31)
Estimation of unbound drug concentration in the brain (Cu,brain) is an essential part of central nervous system (CNS) drug development. As a surrogate for Cu,brain in humans and nonhuman primates, drug concentration in cerebrospinal fluid (CCSF) collected by lumbar puncture
J Vérité et al.
Journal of neuroinflammation, 15(1), 182-182 (2018-06-15)
Alzheimer's disease is widely described since the discovery of histopathological lesions in Mrs. Auguste Deter in 1906. However to date, there is no effective treatment to deal with the many cellular and molecular alterations. The complexity is even higher with
Kamil Nosol et al.
Proceedings of the National Academy of Sciences of the United States of America, 117(42), 26245-26253 (2020-10-07)
ABCB1 detoxifies cells by exporting diverse xenobiotic compounds, thereby limiting drug disposition and contributing to multidrug resistance in cancer cells. Multiple small-molecule inhibitors and inhibitory antibodies have been developed for therapeutic applications, but the structural basis of their activity is

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