Skip to Content
Merck
All Photos(1)

Key Documents

More Documents

SML0939

Sigma-Aldrich

PFI-3

≥98% (HPLC)

Synonym(s):

(E)-1-(2-Hydroxyphenyl)-3-((1R,4R)-5-(pyridin-2-yl)-2,5-diazabicyclo[2.2.1]heptan-2-yl)prop-2-en-1-one

Sign Into View Organizational & Contract Pricing
All Photos(1)

About This Item

Empirical Formula (Hill Notation):
C19H19N3O2
CAS Number:
1819363-80-8
Molecular Weight:
321.37
UNSPSC Code:
12352200
PubChem Substance ID:
329825619
NACRES:
NA.77

Quality Level

100

Assay

≥98% (HPLC)

form

powder

color

yellow to orange

solubility

DMSO: 10 mg/mL, clear

storage temp.

2-8°C

SMILES string

OC1=C(C(/C=C/N2[C@H](C3)CN(C4=NC=CC=C4)[C@H]3C2)=O)C=CC=C1

InChI

1S/C19H19N3O2/c23-17-6-2-1-5-16(17)18(24)8-10-21-12-15-11-14(21)13-22(15)19-7-3-4-9-20-19/h1-10,14-15,23H,11-13H2/b10-8+/t14-,15-/m1/s1

InChI key

INAICWLVUAKEPB-QSTFCLMHSA-N

Related Categories

Biochem/physiol Actions

SMARCA4 (SWI/SNF related, Matrix associated, Actin dependent Regulator of Chromatin, subfamily A, member 4) is a transcriptional activator and is a component of the large ATP-dependent chromatin remodeling complex SWI/SNF, which is required for transcriptional activation of genes normally repressed by chromatin. SMARC4 (also known as BRG1) and the related protein SMARCA2 (also known as BRM) contain a bromodomain that is structurally similar to the PolyBromo1 (PB1) 5 bromodomain. PFI-3 is a selective chemical probe for SMARCA bromodomains that inhibits SMARCA2, SMARCA4 and PB1(5) bromodomains. For full characterization details, please visit the PFI-3 probe summary on the Structural Genomics Consortium (SGC) website.

To learn about other SGC chemical probes for epigenetic targets, visit sigma.com/sgc

Features and Benefits

PFI-3 is an epigenetic chemical probe available through a partnership with the Structural Genomics Consortium (SGC). To learn more and view other SGC epigenetic probes, visit sigma.com/SGC.
This compound is a featured product for Gene Regulation research. Click here to discover more featured Gene Regulation products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

related product

Product No.
Description
Pricing

U4885

UNC0638 hydrate, ≥98% (HPLC)

SML0067

IOX1, ≥97% (HPLC)

SML0352

PFI-1, ≥98% (HPLC)

SML0652

IOX2, ≥98% (HPLC)

SML0662

UNC1215, ≥98% (HPLC)

SML0701

GSK-J4, ≥98% (HPLC)

SML0709

GSK-J1, ≥98% (HPLC)

SML0768

GSK2801, ≥98% (HPLC)

SML0766

GSK343, ≥98% (HPLC)

SML0778

UNC1999, ≥98% (HPLC)

SML0974

(+/-)-JQ1, ≥98% (HPLC)

SML0992

Bromosporine, ≥98% (HPLC)

SML1037

UNC0642, ≥98% (HPLC)

SML1072

GSK-LSD1, ≥98% (HPLC)

SML1107

SGC0946, ≥98% (HPLC)

SML1133

SGC-CBP30, ≥98% (HPLC)

SML1134

I-CBP112, ≥98% (HPLC)

SML1184

OF-1, ≥98% (HPLC)

SML1209

OICR-9429, ≥98% (HPLC)

SML1242

SGC707, ≥98% (HPLC)

SML1279

LLY-507, ≥97% (HPLC)

SML1276

BAZ2-ICR, ≥98% (HPLC)

PZ0307

PFI-4, ≥98% (HPLC)

SML1408

(R)-PFI-2, ≥97% (HPLC)

SML1410

A-366, ≥98% (HPLC)

SML1486

NI-57, ≥98% (HPLC)

PZ0312

(S)-PFI-2

SML1534

I-BRD9, ≥98% (HPLC)

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Customers Also Viewed

Slide 1 of 3

1 of 3

SGC-CBP30 ≥98% (HPLC)

Sigma-Aldrich

SML1133

SGC-CBP30

GSK-LSD1 ≥98% (HPLC)

Sigma-Aldrich

SML1072

GSK-LSD1

(+)-JQ1 ≥98% (HPLC)

Sigma-Aldrich

SML1524

(+)-JQ1

Debolina Ganguly et al.
Stem cells (Dayton, Ohio), 36(12), 1804-1815 (2018-09-02)
Glioblastoma multiforme (GBM) is a highly aggressive and malignant brain tumor that is refractory to existing therapeutic regimens, which reflects the presence of stem-like cells, termed glioma-initiating cells (GICs). The complex interactions between different signaling pathways and epigenetic regulation of
Seul Gi Park et al.
Scientific reports, 10(1), 16330-16330 (2020-10-03)
Bromodomain (BRD), a protein module that recognizes acetylated lysine residues on histones and other proteins, has recently emerged as a promising therapeutic target for human diseases such as cancer. While most of the studies have been focused on inhibitors against
Jin Wei et al.
Cell, 184(1), 76-91 (2020-11-05)
Identification of host genes essential for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection may reveal novel therapeutic targets and inform our understanding of coronavirus disease 2019 (COVID-19) pathogenesis. Here we performed genome-wide CRISPR screens in Vero-E6 cells with SARS-CoV-2
Jovylyn Gatchalian et al.
Nature communications, 9(1), 5139-5139 (2018-12-05)
The role of individual subunits in the targeting and function of the mammalian BRG1-associated factors (BAF) complex in embryonic stem cell (ESC) pluripotency maintenance has not yet been elucidated. Here we find that the Bromodomain containing protein 9 (BRD9) and
Kathrin Laue et al.
Nature communications, 10(1), 1551-1551 (2019-04-06)
The segregation of eukaryotic genomes into euchromatin and heterochromatin represents a fundamental and poorly understood process. Here, we demonstrate that genome-wide establishment of heterochromatin is triggered by the maternal to zygotic transition (MZT) during zebrafish embryogenesis. We find that prior

Related Content

Discover Bioactive Small Molecules for Gene Regulation

We offer a variety of small molecule research tools, such as transcription factor modulators, inhibitors of chromatin modifying enzymes, and agonists/antagonists for target identification and validation in gene regulation research; a selection of these research tools is shown below.

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service