SML0288

Nepafenac

≥98% (HPLC)

• Synonym(s): 2-Amino-3-benzoyl-benzeneacetamide, AHR 9434, AL 6515
• Empirical Formula (Hill Notation): C₁₅H₁₄N₂O₂
• CAS Number: 78281-72-8
• Molecular Weight: 254.28
• MDL number: MFCD08067732
• UNSPSC Code: 12352200
• PubChem Substance ID: 329825296
• NACRES: NA.77

Properties

• Assay: ≥98% (HPLC)
• form: powder
• color: faintly yellow to dark yellow
• solubility: DMSO: ≥5 mg/mL
• storage temp.: room temp
• SMILES string: NC(=O)Cc1cccc(c1N)C(=O)c2ccccc2
• InChI: 1S/C15H14N2O2/c16-13(18)9-11-7-4-8-12(14(11)17)15(19)10-5-2-1-3-6-10/h1-8H,9,17H2,(H2,16,18)
• InChI key: QEFAQIPZVLVERP-UHFFFAOYSA-N
• Gene Information: human ... PTGS1(5742) , PTGS2(5743)

Description

Biochem/physiol Actions

Nepafenac is a NSAID (nonsteroidal anti inflammatory drug) that is routinely used in opthamology to control pain following cataract surgery.

Nepafenac, a prodrug of amfenac, is used in the treatment of diabetic retinopathy. It is metabolized to its active form through intraocular enzymatic hydrolysis. Nepafenac has a molecular weight of 254.28 kDa and effectively penetrates through the cornea. Its molecule structure enables nepafenac to possess better permeability. Nepafenac has a low inhibitory effect on cyclooxygenase.

Safety Information

• Pictograms: GHS09
• Signal Word: Warning
• Hazard Statements: H410
• Precautionary Statements: P273 - P391 - P501
• Hazard Classifications: Aquatic Acute 1 - Aquatic Chronic 1
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable