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SML0266

Sigma-Aldrich

AA 29504

≥98% (HPLC)

Synonym(s):

N-[2-Amino-4-[[(2,4,6-trimethylphenyl)methyl]amino]phenyl]-carbamic acid-ethyl ester

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About This Item

Empirical Formula (Hill Notation):
C19H25N3O2
CAS Number:
945828-50-2
Molecular Weight:
327.42
MDL number:
MFCD19690927
UNSPSC Code:
12352202
PubChem Substance ID:
329825274
NACRES:
NA.77

Quality Level

100

Assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: ≥2 mg/mL

storage temp.

−20°C

SMILES string

CCOC(=O)Nc1ccc(NCc2c(C)cc(C)cc2C)cc1N

InChI

1S/C19H25N3O2/c1-5-24-19(23)22-18-7-6-15(10-17(18)20)21-11-16-13(3)8-12(2)9-14(16)4/h6-10,21H,5,11,20H2,1-4H3,(H,22,23)

InChI key

SCOOTUMXCXKEAD-UHFFFAOYSA-N

Biochem/physiol Actions

AA29504 is a GABAA positive modulator with a preference for extra-synaptic α4β3δ over α1β3γ2s synaptic receptors. AA29504 exhibits anxiolytic effects and reduces motor coordination in rat models.

Features and Benefits

This compound is featured on the GABAA Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H319

Hazard Classifications

Eye Irrit. 2

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

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Christina B Falk-Petersen et al.
Basic & clinical pharmacology & toxicology, 121(2), 119-129 (2017-03-17)
δ-Containing GABAA receptors are located extrasynaptically and mediate tonic inhibition. Their involvement in brain physiology positions them as interesting drug targets. There is thus a continued interest in establishing reliable recombinant expression systems for δ-containing GABAA receptors. Inconveniently, the recombinant

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