SML0152

AK-7

≥98% (HPLC)

• Empirical Formula (Hill Notation): C₁₉H₂₁BrN₂O₃S
• CAS Number: 420831-40-9
• Molecular Weight: 437.35
• MDL number: MFCD03140195
• UNSPSC Code: 12352200
• PubChem Substance ID: 329825200
• NACRES: NA.25

Properties

• Quality Level: 100
• Assay: ≥98% (HPLC)
• form: powder
• color: white to tan
• solubility: DMSO: ≥15 mg/mL
• storage temp.: 2-8°C
• SMILES string: Brc1cccc(NC(=O)c2cccc(c2)S(=O)(=O)N3CCCCCC3)c1
• InChI: 1S/C19H21BrN2O3S/c20-16-8-6-9-17(14-16)21-19(23)15-7-5-10-18(13-15)26(24,25)22-11-3-1-2-4-12-22/h5-10,13-14H,1-4,11-12H2,(H,21,23)
• InChI key: IYAYHZZWYNXHEQ-UHFFFAOYSA-N

Description

General description

AK-7 (3-(1-azepanylsulfonyl)-N-(3-bromphenyl) benzamide) is a cell- and brain-permeable, selective SIRT2 (sirtuin 2) inhibitor.

Application

AK-7 has been used in cell culture and cell treatment.

Biochem/physiol Actions

AK-7 is a brain penetrant selective SIRT2 inhibitor. No inhibition of SIRT1 or SIRT3 detected.

In neurons, the sirtuin 2 inhibitor AK-7 is neuroprotective in vitro and decreases polyglutamine inclusions and cholesterol levels. In mice, treatment with brain-permeable SIRT2 inhibitor AK-7 led to improved motor function, extended survival and decreased brain atrophy. AK-7 decreases the polyglutamine aggregation in R6/2 brain.

Selective SIRT2 Inhibitor

Selective SIRT2 Inhibitor AK-7 is a brain penetrant selective SIRT2 inhibitor. No inhibition of SIRT1 or SIRT3 detected.

Safety Information

• Pictograms: GHS07
• Signal Word: Warning
• Hazard Statements: H319
• Precautionary Statements: P264 - P280 - P305 + P351 + P338 - P337 + P313
• Hazard Classifications: Eye Irrit. 2
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable