SAB5700928

Anti-Insulin-degrading enzyme (IDE) antibody produced in rabbit

• UNSPSC Code: 12352203

Properties

• biological source: rabbit
• Quality Level: 100
• antibody product type: primary antibodies
• clone: monoclonal
• form: liquid
• species reactivity: rat, human, mouse
• concentration: 0.5 mg/mL
• technique(s): western blot: 1:500-1:2000
• UniProt accession no.: P14735
• shipped in: wet ice
• storage temp.: −20°C
• target post-translational modification: unmodified
• Gene Information: human ... IDE(3416)

Description

General description

This gene encodes a zinc metallopeptidase that degrades intracellular insulin, and thereby terminates insulins activity, as well as participating in intercellular peptide signalling by degrading diverse peptides such as glucagon, amylin, bradykinin, and kallidin. The preferential affinity of this enzyme for insulin results in insulin-mediated inhibition of the degradation of other peptides such as beta-amyloid. Deficiencies in this protein's function are associated with Alzheimer's disease and type 2 diabetes mellitus but mutations in this gene have not been shown to be causitive for these diseases. This protein localizes primarily to the cytoplasm but in some cell types localizes to the extracellular space, cell membrane, peroxisome, and mitochondrion. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional transcript variants have been described but have not been experimentally verified.[provided by RefSeq, Sep 2009]

Immunogen

A synthesized peptInsulin-degrading enzyme (Insulin-degrading enzyme (IDE)) derived from human Insulin-degrading enzyme (Insulin-degrading enzyme (IDE))

Physical form

Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.

Safety Information

• Storage Class Code: 12 - Non Combustible Liquids
• WGK: WGK 1
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable