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S8567

Sigma-Aldrich

SU 4312

≥98% (HPLC)

Synonym(s):

3-(4-Dimethylaminobenzylidenyl)-2-indolinone, 3-[[(4-Dimethyl­amino)phenyl]methylene]-1,3-dihydro-2H-indol-2-one, E/Z mixture

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About This Item

Empirical Formula (Hill Notation):
C17H16N2O
CAS Number:
5812-07-7
Molecular Weight:
264.32
MDL number:
MFCD00118147
UNSPSC Code:
51111800
PubChem Substance ID:
24278803
NACRES:
NA.77

Assay

≥98% (HPLC)

form

powder

color

orange

solubility

DMSO: >10 mg/mL
H2O: insoluble

storage temp.

2-8°C

SMILES string

CN(C)c1ccc(cc1)\C=C2\C(=O)Nc3ccccc23

InChI

1S/C17H16N2O/c1-19(2)13-9-7-12(8-10-13)11-15-14-5-3-4-6-16(14)18-17(15)20/h3-11H,1-2H3,(H,18,20)/b15-11+

InChI key

UAKWLVYMKBWHMX-RVDMUPIBSA-N

Gene Information

human ... FLT1(2321)

Application

SU 4312 was used to study angiogenesis during development of zebrafish embryos.2

Biochem/physiol Actions

SU 4312 inhibits the neuronal NOS and exhibits neuroprotection against NO-mediated neurotoxicity. It might be effective in treatment of neurodegenerative disorders.1
SU 4312 is a vascular endothelial growth factor (VEGF) receptor protein tyrosine kinase 1/2 and platelet derived growth factor (PDGF) receptor inhibitor.

Features and Benefits

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Other Notes

This product is a mixture of the cis- and trans- isomers. The ratio is about 55:45 based on HPLC.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Andreas Vogt et al.
Developmental dynamics : an official publication of the American Association of Anatomists, 238(3), 656-663 (2009-02-25)
Presently, the zebrafish is the only vertebrate model compatible with contemporary paradigms of drug discovery. Zebrafish embryos are amenable to automation necessary for high-throughput chemical screens, and optical transparency makes them potentially suited for image-based screening. However, the lack of
Wei Cui et al.
British journal of pharmacology, 168(5), 1201-1214 (2012-10-16)
SU4312, a potent and selective inhibitor of VEGF receptor-2 (VEGFR-2), has been designed to treat cancer. Recent studies have suggested that SU4312 can also be useful in treating neurodegenerative disorders. In this study, we assessed neuroprotection by SU4312 against 1-methyl-4-phenylpyridinium

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