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P4620

Sigma-Aldrich

PD 146176

≥98% (HPLC), solid

Synonym(s):

6,11-Dihydro[1]benzothiopyrano[4,3-b]indole

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About This Item

Empirical Formula (Hill Notation):
C15H11NS
CAS Number:
4079-26-9
Molecular Weight:
237.32
MDL number:
MFCD05664738
UNSPSC Code:
51111800
PubChem Substance ID:
24724579
NACRES:
NA.77

Assay

≥98% (HPLC)

form

solid

color

white to beige

solubility

DMSO: soluble >10 mg/mL
H2O: insoluble

SMILES string

C1Sc2ccccc2-c3[nH]c4ccccc4c13

InChI

1S/C15H11NS/c1-3-7-13-10(5-1)12-9-17-14-8-4-2-6-11(14)15(12)16-13/h1-8,16H,9H2

InChI key

ZGOOPZVQMLHPFM-UHFFFAOYSA-N

Gene Information

human ... ALOX15(246)
mouse ... ALOX15(11687)
rat ... ALOX15(81639)

Application

PD 146176 has been used to study its influence on ex vivo leukotriene B4 (LTB4) and lipoxin A4 (LXA4) secretion in adipose tissue.

Biochem/physiol Actions

PD 146176 blocks neuroprotectin D1 (NPD1) and eicosanoid synthesis by inhibiting the 5-lipoxygenase-1 (15-LOX-1) enzyme.
15-Lipoxygenase inhibitor

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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The selenoenzyme glutathione peroxidase 4 (GPx4) has been described to control specific cyclooxygenases (COXs) and lipoxygenases (LOXs) that exert substantiated functions in tumor growth and angiogenesis. Therefore, we hypothesized a putative regulatory role of GPx4 during tumor progression and created
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