O7635
Anti-Osteopontin antibody produced in goat
affinity isolated antibody, lyophilized powder
Synonym(s):
Anti-OPN
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About This Item
Recommended Products
biological source
goat
Quality Level
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
lyophilized powder
species reactivity
mouse
technique(s)
capture ELISA: 0.2-0.8 μg/mL
immunohistochemistry: 5-15 μg/mL using mouse thymus tissue sections
neutralization: 1-3 μg/mL
western blot: 0.1-0.2 μg/mL
UniProt accession no.
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
mouse ... Spp1(20750)
General description
The OPN (osteopontin) gene is mapped to mouse chromosome 5 E5 and codes for secreted phosphoprotein 1 and is mostly expressed in bone tissue.
Immunogen
purified recombinant mouse osteopontin expressed in NSO cells.
Biochem/physiol Actions
Osteopontin (OPN) serves as a ligand to a number of integrin receptors which are associated with cell motility, chemotaxis, invasion and cell survival. Upregulation of OPN gene is observed in tumors such as colorectal carcinomas, breast cancer and contributes to its pathogenesis. OPN is associated with obesity by mediating adipocyte inflammation and insulin resistance upon macrophage activation. OPN functions as an effector molecule in extracellular signalling and promotes fibrosis and myocyte growth.
Physical form
Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline with 5% trehalose.
Analysis Note
Neutralizes the biological activity of recombinant mouse osteopontin using 293 cells.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
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Suppression of osteopontin inhibits chemically induced hepatic carcinogenesis by induction of apoptosis in mice.
Lee S H, et al.
Oncotarget, 7(52), 87219-87219 (2016)
Osteopontin Deficiency Suppresses Intestinal Tumor Development in Apc-Deficient Min Mice.
Ishigamori R, et al.
International Journal of Molecular Sciences, 18(5), 1058-1058 (2017)
Transcriptome analysis of fetal metatarsal long bones by microarray, as a model for endochondral bone formation.
Sugars R V, et al.
Biochimica et Biophysica Acta (BBA)-Gene Structure and Expression, 1763(10), 1031-1039 (2006)
Tracking the embryonic stem cell transition from ground state pluripotency.
Kalkan T, et al.
Development, dev-142711 (2017)
Massimiliano De Bortoli et al.
European journal of cancer (Oxford, England : 1990), 43(8), 1308-1317 (2007-05-01)
Rhabdomyosarcoma is the most common soft tissue sarcoma of childhood. Improving the management of rhabdomyosarcoma requires a better understanding of growth regulation. Patched haploinsufficient (Ptch+/-) mice spontaneously develop soft tissue sarcomas that resemble human rhabdomyosarcomas. Using microarray profiling and quantitative
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