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M0132

Sigma-Aldrich

5-Methyltetrahydrofolic acid disodium salt

≥88% (UV-vis)

Synonym(s):

5-Methyl-5,6,7,8-tetrahydropteroyl-L-glutamic acid disodium salt, 5-Methyl-THF

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About This Item

Empirical Formula (Hill Notation):
C20H23N7Na2O6
CAS Number:
68792-52-9
Molecular Weight:
503.42
MDL number:
MFCD00070147
UNSPSC Code:
12352204
PubChem Substance ID:
24896534
NACRES:
NA.32

Quality Level

300

Assay

≥88% (UV-vis)

form

powder

solubility

water: 25 mg/mL

shipped in

wet ice

storage temp.

−20°C

SMILES string

[Na+].[Na+].CN1C(CNc2ccc(cc2)C(=O)N[C@H](CCC([O-])=O)C([O-])=O)CNc3nc(N)nc(O)c13

InChI

1S/C20H25N7O6.2Na/c1-27-12(9-23-16-15(27)18(31)26-20(21)25-16)8-22-11-4-2-10(3-5-11)17(30)24-13(19(32)33)6-7-14(28)29;;/h2-5,12-13,22H,6-9H2,1H3,(H,24,30)(H,28,29)(H,32,33)(H4,21,23,25,26,31);;/q;2*+1/p-2

InChI key

KKIWVYLOTHCGRV-UHFFFAOYSA-L

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Biochem/physiol Actions

5-Methyl-THF acts as both cofactor and substrate in the regeneration of methionine from homocysteine through the action of 5-methyl-THF-homocysteine S-methyltransferase.

Packaging

Sealed ampule

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Strawberry cultivar "San Andreas" was grown under ambient (400 ppm CO2, 25 °C) and elevated (950 ppm CO2, 30 °C) growth conditions. The strawberries were subjected to in vitro gastrointestinal digestion and colonic fermentation to examine the accessibility of polyphenols, vitamin C and folates
Joachim Michael Matz et al.
Cell reports, 26(2), 356-363 (2019-01-10)
Folate metabolism is essential for DNA synthesis and a validated drug target in fast-growing cell populations, including tumors and malaria parasites. Genome data suggest that Plasmodium has retained its capacity to generate folates de novo. However, the metabolic plasticity of

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