H2779
HistoChoice® Clearing Agent
alternative to toluene and xylene
Synonym(s):
dewaxing mixture for paraffin tissue sections
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About This Item
UNSPSC Code:
12171500
NACRES:
NA.47
form
liquid
greener alternative product characteristics
Designing Safer Chemicals
Learn more about the Principles of Green Chemistry.
sustainability
Greener Alternative Product
color
colorless
density
0.760-0.820 g/mL
application(s)
hematology
histology
greener alternative category
, Aligned
storage temp.
room temp
General description
HistoChoice® is a patented, complex mixture of agents that allow tissues to retain their structure, antigenic sites, and nucleic acid sites. It is a non-toxic, non-cross-linking fixative formulated to replace formaldehyde-based fixation. This formulation in non-citrus, contains no mercury, formaldehyde, or glutaraldehyde.
We are committed to bringing you Greener Alternative Products, which adhere to one or more of The 12 Principles of Greener Chemistry. This product has Inherently Safer Chemistry, compared to the standard use of formalin for tissue processing.
We are committed to bringing you Greener Alternative Products, which adhere to one or more of The 12 Principles of Greener Chemistry. This product has Inherently Safer Chemistry, compared to the standard use of formalin for tissue processing.
Application
HistoChoice® Clearing Agent has the following applications:
- It is suitable as an alternative to toluene and xylene for dewaxing paraffin tissue sections. Prepared slides are suitable for antibody probing applications and in situ hybridizations.
- It has been employed in a study to explain the recalcitrance of lignocellulosic plant cell walls to enzymatic degradation.
- It has been used to develop a novel method to improve sensitivity for the localization of miRNA and their target transcripts in plants.
- It has been used to study the correlation of cytoplasmic ADP-ribosylation levels with markers of patient outcome in human cancers.
Biochem/physiol Actions
Fixation with HistoChoice® works well in immunohistology applications where its non-cross-linking traits are conducive to epitope retrieval and identification by primary antibodies to extracellular matrix components.
Features and Benefits
- Non-toxic, non-carcinogenic, and odorless.
- Non-flammable.
- Preserves native antigenic and nucleic acid sites.
- Compatible with many organic mounting media.
- Dissolves wax faster and evaporates slower than xylene.
- Can be used in automated processors.
- Tissues retain their original structure.
Legal Information
HistoChoice is a registered trademark of Amresco, Inc.
Signal Word
Warning
Hazard Statements
Precautionary Statements
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
Target Organs
Respiratory system
Storage Class Code
10 - Combustible liquids
WGK
WGK 3
Flash Point(F)
142.0 °F
Flash Point(C)
61.1 °C
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
Certificates of Analysis (COA)
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Sathyanesan Samuel Newton et al.
Brain research. Brain research protocols, 9(3), 214-219 (2002-07-13)
A method is described to perform combined immunohistochemistry and in situ hybridization in mouse brain sections. The protocol is specific to sections mounted on glass slides. In contrast to earlier methods that require either paraffin embedding or perfusion of the
Uthpala Apekshani Jayawardena et al.
Environmental toxicology and chemistry, 36(10), 2855-2867 (2017-05-06)
Heavy metal contamination may have adverse effects on wetland biota, particularly on amphibians. Severe immunotoxic effects elicited in Euphlyctis hexadactylus (Indian green frog) because of metal exposure (Cd, Cr, Cu, Pb, and Zn) in the Bellanwila-Attidiya Sanctuary, a polluted urban
Agata Jedrzejuk et al.
TheScientificWorldJournal, 2012, 749281-749281 (2012-08-25)
During the vase life of cut stems obstruction of xylem vessels occurs due to microbial growth, formation of tyloses, deposition of materials in the lumen of xylem vessels and the presence of air emboli in the vascular system. Such obstructions
Bjarke Veierskov et al.
American journal of botany, 95(6), 766-771 (2008-06-01)
Meristematic activity in the bud meristem of Abies nordmanniana was visualized by ubiquitin immunohistochemical localization from before bud break and throughout shoot expansion. Ubiquitin was detected in meristematic cells either in the cytosol or nucleus, or both, depending on tissue
Xiaojie Li et al.
Journal of integrative plant biology, 60(1), 45-64 (2017-10-06)
RNA editing is a posttranscriptional process that is important in mitochondria and plastids of higher plants. All RNA editing-specific trans-factors reported so far belong to PLS-class of pentatricopeptide repeat (PPR) proteins. Here, we report the map-based cloning and molecular characterization
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