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C9819

Sigma-Aldrich

Chondroitin sulfate A sodium salt from bovine trachea

lyophilized powder, BioReagent, suitable for cell culture

Synonym(s):

Alternating Copoly β-glucuronic acid-(1→3)-N-acetyl-β-galactosamine-4-sulfate-(1→4)

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About This Item

CAS Number:
39455-18-0
MDL number:
MFCD00130792
UNSPSC Code:
12352202
NACRES:
NA.75

biological source

bovine trachea

Quality Level

200

product line

BioReagent

form

lyophilized powder

packaging

poly bottle of 25 g
poly bottle of 5 g

technique(s)

cell culture | mammalian: suitable

surface coverage

20‑2000 μg/cm2

shipped in

ambient

storage temp.

2-8°C

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Application

Chondroitin appears to play a regulatory role for chondrocytes, neural cells, and some tumor cells. Chondroitin sulfate B is used to study ß peptide (1-42) cytotoxicity.

Biochem/physiol Actions

As a large, negatively charged, hydrophilic molecule that is too inflexible to fold into a compact globular structure, chondroitin sulfate molecules form porous hydrated gels, providing mechanical support to tissue and allowing rapid diffusion of water-soluble molecules and migration of cells.

Components

Chondroitin Sulfate A is an acidic mucopolysaccharide found in cartilage, skin, cornea, and umbilical cord. It is composed of alternating N-acetylgalactosamine, D-glucuronic acid, and sulfate residues in equimolar quantities where carbon 4 of the N-acetylgalactosamines is sulfated.

Caution

Store this product at 2-8°C.

Preparation Note

This product is soluble in water at 100 mg/mL.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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USP

USP

1133580

Oversulfated Chondroitin Sulfate

Heparan sulfate proteoglycan ≥400 μg/mL glycosaminoglycan

Sigma-Aldrich

H4777

Heparan sulfate proteoglycan

N Sharma et al.
Osteoarthritis and cartilage, 28(5), 658-668 (2019-11-18)
Links between pain and joint degradation are poorly understood. We investigated the role of activation of Toll-like receptors (TLR) by cartilage metabolites in initiating and maintaining the inflammatory loop in OA causing joint destruction. Synovial membrane explants (SMEs) were prepared
Tomomi Izumikawa et al.
Biochimica et biophysica acta, 1830(10), 4806-4812 (2013-07-03)
Previously, we identified two missense mutations in the chondroitin N-acetylgalactosaminyltransferase-1 gene in patients with neuropathy. These mutations are associated with a profound decrease in chondroitin N-acetylgalactosaminyltransferase-1 enzyme activity. Here, we describe a patient with neuropathy who is heterozygous for a
Gunnar Dick et al.
The Journal of biological chemistry, 288(38), 27384-27395 (2013-08-14)
Chondroitin sulfate (CS) and the CS-rich extracellular matrix structures called perineuronal nets (PNNs) restrict plasticity and regeneration in the CNS. Plasticity is enhanced by chondroitinase ABC treatment that removes CS from its core protein in the chondroitin sulfate proteoglycans or
Philippe Boeuf et al.
PloS one, 6(6), e21126-e21126 (2011-07-07)
In placental malaria, Plasmodium falciparum-infected erythrocytes adhere to the apical plasma membrane of the placental epithelium, triggering an impairment of placental function detrimental to the fetus. The design of anti-adhesion intervention strategies requires a detailed understanding of the mechanisms involved.
Dovile Sinkeviciute et al.
BMC rheumatology, 4, 30-30 (2020-05-20)
Osteoarthritis (OA) is a progressive, chronic disease characterized by articular cartilage destruction. The pro-inflammatory cytokine IL-17 levels have been reported elevated in serum and synovial fluid of OA patients and correlated with increased cartilage defects and bone remodeling. The aim
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