552233

QX-314

≥99% (HPLC), lyophilized solid, voltage-sensitive Na+ conductance blocker, Calbiochem^®

• Synonym(s): QX-314
• Empirical Formula (Hill Notation): C₁₆H₂₇BrN₂O
• CAS Number: 21306-56-9
• Molecular Weight: 343.30
• MDL number: MFCD00083182
• UNSPSC Code: 12352200
• NACRES: NA.77

Properties

• product name: QX-314, A quaternary lidocaine derivative, permanently charged, and lipophobic.
• Quality Level: 100
• Assay: ≥99%
• form: lyophilized solid
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze; protect from light
• solubility: water: 3 mg/mL
• shipped in: ambient
• storage temp.: 10-30°C
• InChI: 1S/C16H26N2O/c1-6-18(7-2,8-3)12-15(19)17-16-13(4)10-9-11-14(16)5/h9-11H,6-8,12H2,1-5H3/p+1
• InChI key: PYEBKOFMWAMBFV-UHFFFAOYSA-O

Description

General description

A quaternary lidocaine derivative, permanently charged, and lipophobic. A powerful blocker of voltage-sensitive Na⁺ conductance when applied intracellularly. Suppresses the generation of Na⁺-dependent spikes from inside the cell membrane, without affecting Ca²⁺ currents or glutamate-activated currents.

Biochem/physiol Actions

Cell permeable: no

Primary Target
A powerful blocker of voltage-sensitive Na+ conductance

Product does not compete with ATP.

Reversible: no

fully active in neurophysiological testing

Warning

Toxicity: Irritant (B)

Other Notes

Mooney, R. 1992. J. Neurosci.12, 2464.
Regehr, W.G. and Tank, D.W. 1992. J. Neurosci.12, 4202.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable