538904

Prostaglandin E₂

Involved in vasodilator actions of kinins such as bradykinin.

• Synonym(s): Prostaglandin E₂, PGE₂
• Empirical Formula (Hill Notation): C₂₀H₃₂O₅
• CAS Number: 363-24-6
• Molecular Weight: 352.47
• MDL number: MFCD00077861
• UNSPSC Code: 12352211

Properties

• Quality Level: 100
• Assay: >98% (HPLC)
• form: solid
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze
• color: white to light yellow
• solubility: acetone: soluble; ethanol: soluble; ethyl acetate: soluble; methanol: soluble
• shipped in: wet ice
• storage temp.: −20°C
• InChI: 1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-17,19,21,23H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/b7-4+,13-12+
• InChI key: XEYBRNLFEZDVAW-RTYMFESYSA-N

Description

General description

Involved in vasodilator actions of kinins such as bradykinin. Inhibits MAP kinase in rat mesangial cells (IC₅₀ = 25-50 µM). Regulates the activity of adenylate cyclase via G-protein coupled receptors.

Biochem/physiol Actions

Cell permeable: no

Primary Target
Involved in vasodilator actions of kinins such as bradykinin

Product does not compete with ATP.

Reversible: no

Target IC₅₀: 25-50 µM inhibiting MAP kinase in rat mesangial cells

Warning

Toxicity: Harmful (C)

Other Notes

Li, X., et al. 1995. Am. J. Physiol.269, C986.
Kessler, W., et al. 1992. Exp. Brain Res.91, 467.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Safety Information

• Pictograms: GHS07,GHS08
• Signal Word: Danger
• Hazard Statements: H302 - H360FD
• Precautionary Statements: P202 - P264 - P280 - P301 + P312 - P308 + P313 - P405
• Hazard Classifications: Acute Tox. 4 Oral - Repr. 1B
• Storage Class Code: 6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 3