428026

Latrunculin A

from Latrunculia magnifica, ≥85% (HPLC), liquid, actin polymerization inhibitor, Calbiochem

• Synonym(s): InSolution Latrunculin A, Latrunculia magnifica
• Empirical Formula (Hill Notation): C₂₂H₃₁NO₅S
• Molecular Weight: 421.55
• UNSPSC Code: 12352200
• NACRES: NA.77

Properties

• product name: Latrunculin A, Latrunculia magnifica, InSolution, ≥85%, 1 mM in DMSO, marine toxin that disrupts microfilament organization in cultured cells
• Quality Level: 100
• Assay: ≥85% (HPLC)
• form: liquid
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze; desiccated (hygroscopic); protect from light
• shipped in: wet ice
• storage temp.: −20°C

Description

General description

A cell-permeable marine toxin from the Red Sea sponge Latrunculia magnifica that disrupts microfilament organization in cultured cells by the formation of a 1:1 complex with monomeric G-actin (K_d = 200 nM). Also a potent inhibitor of microfilament-mediated processes in sperm, eggs, and embryos.

Biochem/physiol Actions

Cell permeable: yes

Primary Target
Inhibitor of microfilament-mediated processes in sperm, eggs, and embryos

Product does not compete with ATP.

Reversible: no

Packaging

Packaged under inert gas

Warning

Toxicity: Harmful (C)

Physical form

A 1 mM (50 µg/119 µl) solution of Latrunculin A, Latrunculia magnifica Cat. No. 428021 in DMSO.

Reconstitution

Following initial use, aliquot and freeze (-20°C).

Other Notes

Ayscough, K.R., et al. 1997. J. Cell Biol.137, 399.
Spector, I., et al. 1989. Cell Motil. Cytoskeleton13, 127.
Coue, M., et al. 1987. FEBS Lett.213, 316.
Schatten, G., et al. 1986. Exp. Cell Res.166, 191.
Spector, I., et al. 1983. Science219, 493.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Safety Information

• Storage Class Code: 10 - Combustible liquids
• WGK: WGK 1
• Flash Point(F): 188.6 °F - (refers to pure substance)
• Flash Point(C): 87 °C - (refers to pure substance)