B-014

Benzoylecgonine-D₈ solution

1.0 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant^®

• Empirical Formula (Hill Notation): C₁₆H₁₁NO₄D₈
• CAS Number: 205446-21-5
• Molecular Weight: 297.38
• UNSPSC Code: 41116107
• NACRES: NA.24

Properties

• grade: certified reference material
• form: liquid
• feature: SNAP-N-SPIKE^®, SNAP-N-SHOOT^®
• packaging: ampule of 1 mL
• manufacturer/tradename: Cerilliant^®
• drug control: Narcotic Licence Schedule A (Switzerland); estupefaciente (Spain); Decreto Lei 15/93: Tabela IB (Portugal)
• concentration: 1.0 mg/mL in methanol
• technique(s): gas chromatography (GC): suitable; liquid chromatography (LC): suitable
• application(s): forensics and toxicology
• format: single component solution
• storage temp.: −20°C
• InChI: 1S/C16H19NO4/c1-17-11-7-8-12(17)14(15(18)19)13(9-11)21-16(20)10-5-3-2-4-6-10/h2-6,11-14H,7-9H2,1H3,(H,18,19)/t11-,12-,13+,14+/m1/s1/i1D3,2D,3D,4D,5D,6D
• InChI key: GVGYEFKIHJTNQZ-GDERWKOJSA-N

Description

General description

A stable-labeled internal standard suitable for isotope dilution methods or benzoylecgonine testing in urine, saliva, blood, or hair by GC/MS or LC/MS for applications in clinical toxicology, urine drug testing, pain prescription monitoring or forensic analysis. Benzoylecgonine is the primary metabolite of cocaine and a major biomarker for determination of cocaine use.

Application

• LC-MS/MS for Rapid Detection: A study on the rapid determination of cocaine and its metabolite benzoylecgonine in hair by liquid chromatography-tandem mass spectrometry (LC-MS/MS) underscores the utility of Benzoylecgonine-D₈ as an internal standard in forensic toxicology, enhancing the reliability and sensitivity of drug detection methods (Pan et al., 2018).


• Single Dose Administration Analysis: Research focused on the determination of cocaine and benzoylecgonine in guinea pig hair following a single dose administration by LC-MS/MS, illustrating how Benzoylecgonine-D₈ serves as an essential internal standard for studying the pharmacokinetics and metabolic profiling of cocaine in scientific and medical research (Sun et al., 2008).

Legal Information

CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany

Snap-N-Shoot is a registered trademark of Cerilliant Corporation

Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany

Safety Information

• Pictograms: GHS02,GHS06,GHS08
• Signal Word: Danger
• Hazard Statements: H225,H301 + H311 + H331,H370
• Precautionary Statements: P210 - P280 - P301 + P310 + P330 - P302 + P352 + P312 - P304 + P340 + P311
• Hazard Classifications: Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1
• Target Organs: Eyes
• Storage Class Code: 3 - Flammable liquids
• WGK: WGK 1
• Flash Point(F): 49.5 °F - closed cup
• Flash Point(C): 9.7 °C - closed cup