D26202
3,5-Diamino-1,2,4-triazole
98%
Synonym(s):
Guanazole
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About This Item
Empirical Formula (Hill Notation):
C2H5N5
CAS Number:
Molecular Weight:
99.09
Beilstein:
112467
EC Number:
MDL number:
UNSPSC Code:
12352100
PubChem Substance ID:
NACRES:
NA.22
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Quality Level
Assay
98%
form
solid
mp
202-205 °C (lit.)
SMILES string
Nc1n[nH]c(N)n1
InChI
1S/C2H5N5/c3-1-5-2(4)7-6-1/h(H5,3,4,5,6,7)
InChI key
PKWIYNIDEDLDCJ-UHFFFAOYSA-N
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Application
Inhibitor of DNA synthesis.
Signal Word
Warning
Hazard Statements
Precautionary Statements
Hazard Classifications
Aquatic Chronic 2 - Repr. 2 - STOT RE 2
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
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V M Kolb et al.
Journal of molecular evolution, 38, 549-557 (1994-01-01)
Urazole is a five-membered heterocyclic compound which is isosteric with uracil's hydrogen-bonding segment. Urazole reacts spontaneoulsy with ribose (and other aldoses) to give a mixture of four ribosides: alpha and beta pyranosides and furanosides. This reaction occurs in aqueous solution
A A Alhaider et al.
Journal of pharmaceutical sciences, 71(1), 89-94 (1982-01-01)
A series of guanazole prodrugs, which are less water soluble than the parent compound and have relatively higher molecular weights, was recently synthesized, and their antineoplastic activities were measured in vitro. In present work, the ionization constants and partition coefficients
C Loganathan et al.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, 173, 837-842 (2016-11-07)
Detection of a chromogenic insecticide, malachite green (MG) using 3,5-diamino-1,2,4-triazole capped gold nanoparticles (DAT-AuNPs) by both naked eye and spectrophotometry was described in this paper. The DAT-AuNPs were prepared by wet chemical method and show absorption maximum at 518nm. The
Inhibition of ribonucleotide reductases encoded by herpes simplex viruses.
T Spector
Pharmacology & therapeutics, 31(3), 295-302 (1985-01-01)
G Tipples et al.
Journal of bacteriology, 173(16), 4932-4940 (1991-08-01)
Chlamydiae are obligate intracellular bacteria that are dependent on eukaryotic host cells for ribonucleoside triphosphates but not deoxyribonucleotide triphosphates. Ribonucleotide reductase is the only enzyme known to catalyze the direct conversion of a ribonucleotide to a deoxyribonucleotide. Hydroxyurea inhibits ribonucleotide
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