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700312

Sigma-Aldrich

Iron oxide(II,III), magnetic nanoparticles solution

10 nm avg. part. size, 5 mg/mL in toluene

Synonym(s):

Magnetic iron oxide nanocrystals, Magnetite, Superparamagnetic iron oxide nanoparticles

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About This Item

Empirical Formula (Hill Notation):
Fe3O4
CAS Number:
1317-61-9
Molecular Weight:
231.53
MDL number:
MFCD00011010
UNSPSC Code:
12352302
PubChem Substance ID:
329762195
NACRES:
NA.23

form

nanoparticles
solution

concentration

5 mg/mL in toluene

magnetization

>45 emu/g (at ambient temperature under 4500 Oe)

avg. part. size

10 nm

particle size

9-11 nm (TEM; conforms)

density

0.865 g/mL at 25 °C

SMILES string

O=[Fe].O=[Fe]O[Fe]=O

InChI

1S/3Fe.4O

InChI key

SZVJSHCCFOBDDC-UHFFFAOYSA-N

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General description

Iron oxide(II,III), magnetic nanoparticles solution (Fe3O4) is an organic solvent dispersed nanoparticle solution, which can be synthesized by the thermal decomposition of iron acetylacetonate in 2-pyrrolidone. It is majorly used in biomedical applications due to its magnetic properties, particle size, and surface properties.
It contains <1.0% oleic acid stabilizing ligands.
Concentration 5mg/ml includes total weight nanocrystals plus ligands.

Application

Fe3O4 can be used in the targeting and imaging of tumor cells for cancer therapy-based applications. It may also be used in the separation of tumor cells from fresh whole blood. It can also be used as an effective material in drug delivery systems and magnetic resonance imaging (MRI).

Signal Word

Danger

Hazard Classifications

Aquatic Chronic 3 - Asp. Tox. 1 - Flam. Liq. 2 - Repr. 2 - Skin Irrit. 2 - STOT RE 2 - STOT SE 3

Target Organs

Central nervous system

Storage Class Code

3 - Flammable liquids

WGK

WGK 3

Flash Point(F)

45.0 °F

Flash Point(C)

7.2 °C

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
MKCQ3040
MKCM5927
MKCK4363
MKBZ5894V
MKBZ1033V

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Nonpolymeric coatings of iron oxide colloids for biological use as magnetic resonance imaging contrast agents
Portet D, et al.
Journal of Colloid and Interface Science, 238(1), 37-42 (2001)
Superparamagnetic nanoparticles for biomedical applications: possibilities and limitations of a new drug delivery system
Neuberger T, et al.
Journal of magnetism and magnetic materials, 293(1), 483-496 (2005)
Antibody conjugated magnetic iron oxide nanoparticles for cancer cell separation in fresh whole blood
Xu H, et al.
Biomaterials, 32(36), 9758-9765 (2011)
Targeted magnetic iron oxide nanoparticles for tumor imaging and therapy
Peng X, et al.
International journal of nanomedicine, 3(3), 311-311 (2008)
Synthesis of Fe3O4 nanoparticles with various sizes and magnetic properties by controlled hydrolysis
Iida H, et al.
Journal of Colloid and Interface Science, 314(1), 274-280 (2007)
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