556815

3-Ethyl-4-methyl-3-pyrrolin-2-one

97%

• Empirical Formula (Hill Notation): C₇H₁₁NO
• CAS Number: 766-36-9
• Molecular Weight: 125.17
• MDL number: MFCD00173861
• UNSPSC Code: 12352100
• PubChem Substance ID: 24879585
• NACRES: NA.22

Properties

• Assay: 97%
• mp: 100-104 °C (lit.)
• SMILES string: CCC1=C(C)CNC1=O
• InChI: 1S/C7H11NO/c1-3-6-5(2)4-8-7(6)9/h3-4H2,1-2H3,(H,8,9)
• InChI key: YCTNTSVMJWIYTQ-UHFFFAOYSA-N

Description

General description

3-Ethyl-4-methyl-3-pyrrolin-2-one, a five-membered α,β-unsaturated lactam derivative, has various applications in medicinal chemistry. It can be synthesized by employing following as starting materials:

• allylamine, via palladium(II)-assisted cyclization
• 4-methoxybenzylamine, via a ring-closing-metathesis strategy
• 3-ethyl-1-(4-methoxybenzyl)-4-methyl-1,5-dihydro-2H-pyrrol-2- one

Application

3-Ethyl-4-methyl-3-pyrrolin-2-one (3-Ethyl-4-methyl-1,5-dihydro-2H-pyrrol-2-one) may be employed as a precursor for the synthesis of glimepiride (antidiabetic drug) and its derivatives (sulfonylurea drugs). It may also be employed for the preparation of 2-ethyl-3-methyl-(10H)-
dipyrrin-1-one.

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves