278823

4-Chloro-1-butanol

technical grade, ~85%

• Synonym(s): Tetramethylene chlorohydrin
• Linear Formula: HO(CH₂)₄Cl
• CAS Number: 928-51-8
• Molecular Weight: 108.57
• Beilstein: 1731408
• MDL number: MFCD00002967
• UNSPSC Code: 12352100
• PubChem Substance ID: 24856834
• NACRES: NA.22

Properties

• grade: technical grade
• Quality Level: 200
• Assay: ~85%
• form: liquid
• refractive index: n20/D 1.453 (lit.)
• bp: 84-85 °C/16 mmHg (lit.)
• density: 1.088 g/mL at 25 °C (lit.)
• functional group: chloro; hydroxyl
• storage temp.: 2-8°C
• SMILES string: OCCCCCl
• InChI: 1S/C4H9ClO/c5-3-1-2-4-6/h6H,1-4H2
• InChI key: HXHGULXINZUGJX-UHFFFAOYSA-N

Description

General description

4-Chloro-1-butanol, an alkylating agent, is one of the genotoxic impurity in active pharmaceutical ingredients. Reaction of 4-chloro-1-butanol and Reichardt′s dye has been monitored spectrophotometrically for the determination of genotoxic impurities in pharmaceuticals.

Application

4-Chloro-1-butanol was employed as an internal standard in the analysis of genotoxic impurities in active pharmaceutical ingredients by GC-MS technique.

Other Notes

Contains tetrahydrofuran and HCl

Safety Information

• Pictograms: GHS02,GHS08,GHS05,GHS07
• Signal Word: Warning
• Hazard Statements: H226,H290,H302,H315,H319,H335,H351
• Precautionary Statements: P202 - P210 - P301 + P312 - P303 + P361 + P353 - P305 + P351 + P338 - P308 + P313
• Hazard Classifications: Acute Tox. 4 Oral - Carc. 2 - Eye Irrit. 2 - Flam. Liq. 3 - Met. Corr. 1 - Skin Irrit. 2 - STOT SE 3
• Target Organs: Respiratory system
• Supplementary Hazards: EUH019
• Storage Class Code: 3 - Flammable liquids
• WGK: WGK 3
• Flash Point(F): 96.8 °F - closed cup
• Flash Point(C): 36 °C - closed cup
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves