20019AST

Astec^® CYCLOBOND I 2000 Chiral (5 μm) HPLC Columns

L × I.D. 15 cm × 2.1 mm, HPLC Column

• Synonym(s): CYCLOBOND I 2000 Cyclodextrin-Based Chiral Column
• UNSPSC Code: 41115700
• eCl@ss: 32110501
• NACRES: SB.52

Properties

• product name: Astec^® CYCLOBOND I 2000 Chiral HPLC Column, 5 μm particle size, L × I.D. 15 cm × 2.1 mm
• material: stainless steel column
• product line: Astec^®
• packaging: pkg of 1 ea
• manufacturer/tradename: Astec^®
• parameter: 0-50 °C temperature; 172 bar pressure (2500 psi)
• technique(s): HPLC: suitable; LC/MS: suitable
• L × I.D.: 15 cm × 2.1 mm
• matrix: silica particle platform
• matrix active group: cyclodextrin, beta- phase
• particle size: 5 μm
• pore size: 100 Å
• operating pH: 3.5-7
• separation technique: chiral

Description

General description

CYCLOBOND I 2000 is bonded with β-cyclodextrin by a patented process to produce a stable matrix with the cyclodextrin arranged in such a way as to retain its most valuable property of forming inclusion complexes. This allows them to effect numerous chemical separations by selectively including into their cavities a wide variety of organic molecules. Non-inclusion type separations are also possible with the polar organic mode for a wide variety of molecule types.

• Bonded phase: Underivatized, native β-cyclodextrin

Resources:
CYCLOBOND FAQs
CYCLOBOND Reference Bibliography
Chiral Product Literature

Application

• Thioether bridged cationic cyclodextrin stationary phases: Effect of spacer length, selector concentration and rim functionalities on the enantioseparation.: This study investigates the effect of different variables on the enantioseparation efficiency of thioether bridged cationic cyclodextrin stationary phases, utilizing the Astec CYCLOBOND 2000 Chiral HPLC Column for the separation processes (Li et al., 2016).


• Enantiomeric separations of illicit drugs and controlled substances using cyclofructan-based (LARIHC) and cyclobond I 2000 RSP HPLC chiral stationary phases.: This research explores the use of cyclobond I 2000 RSP HPLC chiral stationary phases, including Astec CYCLOBOND 2000, in the enantiomeric separation of various illicit drugs and controlled substances (Padivitage et al., 2014).


• Screening approach, optimisation and scale-up for chiral liquid chromatography of cathinones.: The paper discusses a screening approach and optimization methods for chiral liquid chromatography of cathinones, highlighting the application of Astec CYCLOBOND 2000 Chiral HPLC Column in these processes (Perera et al., 2012).


• Stereoselective analysis of hydroxybupropion and application to drug interaction studies.: This study focuses on the stereoselective analysis of hydroxybupropion using chiral stationary phases, including Astec CYCLOBOND 2000, to explore drug interaction effects (Xu et al., 2007).


• Solid-phase extraction of methadone enantiomers and benzodiazepines in biological fluids by two polymeric cartridges for liquid chromatographic analysis.: This research investigates the extraction and analysis of methadone enantiomers and benzodiazepines in biological fluids using the Astec CYCLOBOND 2000 Chiral HPLC Column for effective separation (He et al., 2005).

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Legal Information

Astec is a registered trademark of Merck KGaA, Darmstadt, Germany