T6381

N,O-Bis(trimethylsilyl)trifluoroacetamide with trimethylchlorosilane

with 1% trimethylchlorosilane, for GC derivatization, LiChropur^™

• Synonym(s): BSTFA + TMCS
• Linear Formula: CF₃C[=NSi(CH₃)₃]OSi(CH₃)₃
• CAS Number: 25561-30-2
• Molecular Weight: 257.40
• Beilstein: 2050024
• MDL number: MFCD00008269
• UNSPSC Code: 12000000
• PubChem Substance ID: 24900370

Properties

• grade: for GC derivatization
• Quality Level: 100
• quality: LiChropur^™; with 1% trimethylchlorosilane
• contains: 1% trimethylchlorosilane as additive
• reaction suitability: reagent type: derivatization reagent; reaction type: Silylations
• technique(s): gas chromatography (GC): suitable
• color: hazy clear to colorless
• refractive index: n20/D 1.384 (lit.)
• bp: 45-50 °C/14 mmHg (lit.)
• solubility: hexane: miscible 100 mg/mL
• density: 0.97 g/mL (lit.)
• storage temp.: 2-8°C
• SMILES string: C[Si](C)(C)O\C(=N\[Si](C)(C)C)C(F)(F)F
• InChI: 1S/C8H18F3NOSi2/c1-14(2,3)12-7(8(9,10)11)13-15(4,5)6/h1-6H3/b12-7+
• InChI key: XCOBLONWWXQEBS-KPKJPENVSA-N

Description

General description

N,O-Bis(trimethylsilyl)trifluoroacetamide with trimethylchlorosilane is a silylating reagent generally used in estrogenic steroid hormone identification and quantification.

Application

BSTFA+TMCS has been used as derivatizing reagent for GC-MS determination of natural and synthetic estrogenic steroids.

Packaging

Clear borosilicate glass, high hydrolytic resistance (Type I)

Sealed ampules contain 1 ml. Gram sizes are in screw-cap bottles.

Other Notes

The position of the silyl groups has not been unequivocally established. It has been referred to as both N,N and N,O.

Legal Information

LiChropur is a trademark of Merck KGaA, Darmstadt, Germany

Safety Information

• Pictograms: GHS02,GHS07
• Signal Word: Danger
• Hazard Statements: H225 - H315 - H319
• Precautionary Statements: P210 - P233 - P240 - P241 - P303 + P361 + P353 - P305 + P351 + P338
• Hazard Classifications: Eye Irrit. 2 - Flam. Liq. 2 - Skin Irrit. 2
• Storage Class Code: 3 - Flammable liquids
• WGK: WGK 3
• Flash Point(F): 44.1 °F - closed cup
• Flash Point(C): 6.7 °C - closed cup
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves