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SML3208

Sigma-Aldrich

CPYPP

≥98% (HPLC)

Synonym(s):

4-[3′-(2′′-chlorophenyl)-2′-propen-1′-ylidene]-1-phenyl-3,5-pyrazolidinedione

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About This Item

Empirical Formula (Hill Notation):
C18H13ClN2O2
CAS Number:
310460-39-0
Molecular Weight:
324.76
MDL number:
MFCD00980987
UNSPSC Code:
51111800
NACRES:
NA.77

Quality Level

100

Assay

≥98% (HPLC)

form

powder

color

orange to dark red

solubility

DMSO: 2 mg/mL, clear

storage temp.

−20°C

SMILES string

Clc1c(cccc1)C=CC=C2C(=O)N(NC2=O)c3ccccc3

InChI

1S/C18H13ClN2O2/c19-16-12-5-4-7-13(16)8-6-11-15-17(22)20-21(18(15)23)14-9-2-1-3-10-14/h1-12H,(H,20,22)

Biochem/physiol Actions

CPYPP is a cell permeable potent and selective reversible inhibitor of DOCK2 that binds to DOCK2 DHR-2 domain. CPYPP is a DOCK2-Rac1 interaction inhibitor. It also inhibits DOCK1 and DOCK5. CPYPP potently inhibits metastatic spread of aggressive ROBO1deficient prostate cancer cells through the vasculature of transgenic Zebrafish model.

Storage Class Code

11 - Combustible Solids

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