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Key Documents

SAB4503057

Sigma-Aldrich

Anti-PGP9.5 antibody produced in rabbit

affinity isolated antibody

Synonym(s):

UCH-L1, neuron cytoplasmic protein 9.5, ubiquitin carboxyl-terminal hydrolase isozyme L1, ubiquitin thiolesterase L1

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

biological source

rabbit

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

antigen 24 kDa

species reactivity

mouse, rat, human

concentration

~1 mg/mL

technique(s)

ELISA: 1:5000
immunohistochemistry: 1:50-1:100
western blot: 1:500-1:1000

UniProt accession no.

P09936

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... UCHL1(7345)

General description

Anti-PGP9.5 Antibody detects endogenous levels of total PGP9.5 protein.
The PGP9.5 (protein gene product 9.5) gene is mapped to human chromosome 4p13. The encoded protein is predominantly expressed in the brain.

Immunogen

The antiserum was produced against synthesized peptide derived from human PGP9.5.

Immunogen Range: 171-220

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Physical form

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

12 - Non Combustible Liquids

WGK

nwg

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Manasi Sayilekshmy et al.
Scientific reports, 9(1), 5361-5361 (2019-03-31)
Mounting evidence from animal studies suggests a role of the nervous system in bone physiology. However, little is known about the nerve fiber localization to human bone compartments and bone surface events. This study reveals the density and distribution of
Iris Shinkarevsky Fleitman et al.
Muscle & nerve, 61(6), 791-796 (2020-03-07)
Small-fiber neuropathy is rare in children. It has been associated with several autoimmune disorders, but there are no reports of an autoinflammatory etiology. The data of four children/adolescents presenting with erythromelalgia and neuropathic pain from 2014 to 2019 were collected
Mitochondria: The Next (Neurode)Generation
Schon EA, et al.
Neuron, 70(6), 1033-1053 (2011)
Familial Mutations and Post-translational Modifications of UCH-L1 in Parkinson's Disease and Neurodegenerative Disorders.
C Lee YT, et al.
Current Protein and Peptide Science, 18(7), 733-745 (2017)
Rie B Hansen et al.
Frontiers in pain research (Lausanne, Switzerland), 3, 887747-887747 (2022-06-18)
Pain is a common complication for patients with metastatic bone disease. Animal models suggest that the pain, in part, is driven by pathological sprouting and reorganization of the nerve fibers innervating the bone. Here, we investigate how these findings translate
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