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Key Documents

SAB2500068

Sigma-Aldrich

Anti-Androgen Receptor antibody produced in goat

affinity isolated antibody, buffered aqueous solution

Synonym(s):

Anti-AIS, Anti-AR, Anti-Dihydrotestosterone receptor, Anti-KD, Anti-TFM

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About This Item

MDL number:
MFCD01321686
UNSPSC Code:
12352203
NACRES:
NA.41

biological source

goat

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

species reactivity

human

technique(s)

ChIP: suitable
immunohistochemistry: suitable
indirect ELISA: suitable
western blot: suitable

UniProt accession no.

P10275

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... AR(367)

Related Categories

General description

Androgen receptor (AR) is a nuclear transcription factor. It belongs to the steroid hormone receptor superfamily. AR gene is located on human chromosome Xq12. AR is present in endothelial and vascular smooth muscle cells.

Immunogen

Peptide with sequence EVQLGLGRVYPRPPSC from the N Terminus of the protein sequence according to NP_000035.2.

Biochem/physiol Actions

Androgens like testosterone and 5α-dihydrotestosterone are required for the progression, growth, differentiation and maintenance of organ structure of the prostate. It plays a major role in normal and malignant breast tissue.

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Physical form

Supplied at 0.5 mg/mL in Tris saline with 0.02% sodium azide and 0.5% bovine serum albumin.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H315,H319

Precautionary Statements

P305 + P351 + P338

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2

Storage Class Code

10 - Combustible liquids

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Androgen receptor expression on circulating tumor cells in metastatic breast cancer.
Fujii T, et al.
PLoS ONE, 12(9), e0185231-e0185231 (2016)
The CAG repeat polymorphism in the AR gene affects high density lipoprotein cholesterol and arterial vasoreactivity.
Zitzmann M, et al.
The Journal of Clinical Endocrinology and Metabolism, 86(10), 4867-4873 (2001)
FISH analysis of gene aberrations (MYC, CCND1, ERBB2, RB, and AR) in advanced prostatic carcinomas before and after androgen deprivation therapy.
Kaltz-Wittmer C, et al.
Laboratory Investigation; a Journal of Technical Methods and Pathology, 80(9), 1455?1464-1455?1464 (2000)
Melissa A Babcook et al.
Molecular cancer therapeutics, 13(10), 2288-2302 (2014-08-15)
Docetaxel chemotherapy remains a standard of care for metastatic castration-resistant prostate cancer (CRPC). Docetaxel modestly increases survival, yet results in frequent occurrence of side effects and resistant disease. An alternate chemotherapy with greater efficacy and minimal side effects is needed.

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