Q3251

Quinacrine dihydrochloride

≥90% (TLC), powder, MAO-A/B inhibitor

• Synonym(s): 6-Chloro-9-(4-diethylamino-1-methylbutylamino)-2-methoxyacridine dihydrochloride, Atebrin dihydrochloride, Mepacrine dihydrochloride
• Empirical Formula (Hill Notation): C₂₃H₃₀ClN₃O · 2HCl
• CAS Number: 69-05-6
• Molecular Weight: 472.88
• Beilstein: 4834013
• EC Number: 200-700-8
• MDL number: MFCD00012659
• UNSPSC Code: 12352101
• PubChem Substance ID: 24278192
• NACRES: NA.77

Properties

• product name: Quinacrine dihydrochloride, ≥90%
• biological source: synthetic
• Assay: ≥90%
• form: powder
• mp: 257 °C
• solubility: H₂O: soluble, clear to hazy
• originator: Bayer
• SMILES string: Cl[H].Cl[H].CCN(CC)CCCC(C)Nc1c2ccc(Cl)cc2nc3ccc(OC)cc13
• InChI: 1S/C23H30ClN3O.2ClH/c1-5-27(6-2)13-7-8-16(3)25-23-19-11-9-17(24)14-22(19)26-21-12-10-18(28-4)15-20(21)23;;/h9-12,14-16H,5-8,13H2,1-4H3,(H,25,26);2*1H
• InChI key: UDKVBVICMUEIKS-UHFFFAOYSA-N
• Gene Information: human ... MAOA(4128) , MAOB(4129)

Description

General description

Quinacrine is an acridine derivative and a potent antimalarial agent.

Application

Quinacrine dihydrochloride has been used:

• in its uptake and accumulation studies in mouse lung slices using fluorescence microscope
• in the staining of ATP vesicles in mesenchymal stem cells (MSCs)
• in uptake-release assay for characterization of dense granule functionality of platelets

Biochem/physiol Actions

Quinacrine has anthelmintic functionality and used in the female sterilization. It is used to treat systemic lupus erythematosus and rheumatic diseases. Apart from malaria, Quinacrine is effective for treating giardia and tapeworm infections. It inhibits nicotinamide adenine dinucleotide phosphate (NADPH) oxidase activity in addition to monoamine oxidase inhibition.

Non-selective MAO-A/B inhibitor.

Features and Benefits

This compound was developed by Bayer. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Safety Information

• Pictograms: GHS07
• Signal Word: Warning
• Hazard Statements: H302
• Precautionary Statements: P264 - P270 - P301 + P312 - P501
• Hazard Classifications: Acute Tox. 4 Oral
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves