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N4143

Sigma-Aldrich

Neurokinin B

≥95% (HPLC)

Synonym(s):

β-Neurokinin, Neuromedin K

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About This Item

Empirical Formula (Hill Notation):
C55H79N13O14S2
CAS Number:
86933-75-7
Molecular Weight:
1210.42
MDL number:
MFCD00133665
UNSPSC Code:
51111800
PubChem Substance ID:
24897694
NACRES:
NA.32

Quality Level

200

Assay

≥95% (HPLC)

form

powder

UniProt accession no.

Q9UHF0

storage temp.

−20°C

SMILES string

CSCCC(NC(=O)C(CC(C)C)NC(=O)CNC(=O)C(NC(=O)C(Cc1ccccc1)NC(=O)C(Cc2ccccc2)NC(=O)C(CC(O)=O)NC(=O)C(Cc3cnc[nH]3)NC(=O)C(CCSC)NC(=O)C(N)CC(O)=O)C(C)C)C(N)=O

InChI

1S/C55H79N13O14S2/c1-30(2)21-38(50(77)62-36(47(57)74)17-19-83-5)61-43(69)28-59-55(82)46(31(3)4)68-54(81)40(23-33-15-11-8-12-16-33)65-51(78)39(22-32-13-9-7-10-14-32)64-53(80)42(26-45(72)73)67-52(79)41(24-34-27-58-29-60-34)66-49(76)37(18-20-84-6)63-48(75)35(56)25-44(70)71/h7-16,27,29-31,35-42,46H,17-26,28,56H2,1-6H3,(H2,57,74)(H,58,60)(H,59,82)(H,61,69)(H,62,77)(H,63,75)(H,64,80)(H,65,78)(H,66,76)(H,67,79)(H,68,81)(H,70,71)(H,72,73)

InChI key

NHXYSAFTNPANFK-UHFFFAOYSA-N

Gene Information

human ... TAC3(6866)

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Amino Acid Sequence

Asp-Met-His-Asp-Phe-Phe-Val-Gly-Leu-Met-NH2

Biochem/physiol Actions

Neurokinin B is a ten-residue peptide. It is an endogenous tachykinin agonist with preference for the NK-3 receptor. It is a potent bronchoconstrictor and may have a neuromodulatory role in the brain. Neurokinin B has a role in slow synaptic or non-synaptic communication.

Other Notes

Lyophilized from 0.1% TFA in H2O

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Neurokinin B Acts via the Neurokinin-3 Receptor in the Retrochiasmatic Area to Stimulate Luteinizing Hormone Secretion in Sheep
Endocrinology (2010)
Emilie Caron et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 32(33), 11486-11494 (2012-08-17)
It is increasingly accepted that alterations of the early life environment may have lasting impacts on physiological functions. In particular, epidemiological and animal studies have indicated that changes in growth and nutrition during childhood and adolescence can impair reproductive function.
Christina M Merkley et al.
Endocrinology, 153(11), 5406-5414 (2012-09-20)
KNDy (kisspeptin/neurokinin B/dynorphin) neurons of the arcuate nucleus (ARC) appear to mediate the negative feedback actions of estradiol and are thought to be key regulators of pulsatile LH secretion. In the ewe, KNDy neurons may also be involved with the
Robert P Millar et al.
Nature reviews. Endocrinology, 9(8), 451-466 (2013-07-03)
Reproductive hormones affect all stages of life from gamete production, fertilization, fetal development and parturition, neonatal development and puberty through to adulthood and senescence. The reproductive hormone cascade has, therefore, been the target for the development of numerous drugs that
Neurokinin B- and specific tachykinin NK3 receptor agonists-induced airway hyperresponsiveness in the guinea-pig
Samira D
British Journal of Pharmacology (2000)
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